IN VIVO EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SOLID DISPERSIONS OF GLIBENCLAMIDE USING PREGELATINISED STARCH AS A SOLUBILITY ENHANCER
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
Current study was undertaken to investigate the aptness of pregelatinised starch to get better solubility and In vitro dissolution rate of the poorly water soluble drug glibenclamide. Physical mixtures, kneading mixtures and solid dispersions of glibenclamide & pregelatinised starch were prepared at drug carrier ratio 1:1, 1:3, 1:5, 1:7 and 1:9. These resulting systems were subjected to solubility analysis, In vitro dissolution, X-ray diffraction, differential scanning calorimetry and Infrared Fourier Transform Spectroscopy (FTIR) to characterize the resulting systems. All systems fashioned improvement of the solubility of glibenclamide, however solvent evaporation method was realistic to offer the superior solubility and dissolution rates. In vitro dissolution studies of solid dispersion of glibenclamide with pregelatinised starch at 1:9 drug carrier ratio discovered utmost dissolution (39.15 %) after 120 minutes in comparison with pure drug (3.27%).This improvement in in-vitro dissolution was accredited to amorphous form which is revealed by DSC and R-ray diffraction studies. In vivo evaluation of the selected solid dispersions significantly enhanced hypoglycemia attributed to improvement in superior gastrointestinal solubility of the drug in solid dispersions.
Authors and Affiliations
Dinesh Sharma , Vipin Gupta , Suresh Purohit
Keywords
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