ANTITUMOR ACTIVITY OF METHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST EHRLICH ASCITES INDUCED CARCINOMA IN MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Terminalia catappa belongs to the family combretaceae and is popularly known as badam.It is a well known herb in Ayurvedic system of medicine The aim of the present study is to evaluate the effect of methanolic extract of leaves of Terminalia catappa against Ehrlich ascetic Lymphoma (ELA) in Swiss albino mice.The tumor was induced in mice by intraperitoneal injection of ELA cells (1X106cells/mice). Methanolic extract of Terminalia catappa was administered to the experimental animals at a dose of 75µg/kg/day after 24 h of tumor inoculation. The antitumor effect of extract was evaluated by assessing in vitro cytotoxicity, increase in lifespan, hematological parameters and liver enzymes. The methanolic extract brought back the altered levels of the hematological parameters and liver enzymes. Thus the present study revealed that methanolic extract of Terminalia catappa possessed significant antitumor activity.
Authors and Affiliations
M Saroja , S Annapoorani
Keywords
Related Articles
- EP ID EP108578
- DOI -
- Views 91
- Downloads 0
REVIEW ON ALBIZIA LEBBECK A POTENT HERBAL DRUG
Herbs and herbal drugs have created interest among the people by the clinically proven effects like immunomodulatios, adaptogenic and antimutagenic. Also the overuse of synthetic drug, which results in higher incidence o...
EFFECT OF 6-BENZYL AMINO PURINE HORMONE ON THE SHOOTING GROWTH OF OCIMUM GRATISSIMUM L.
BAP (benzyl amino purine) is a cytokine hormone. It causes the shooting effect in plants. We used different concentrations of BAP in MS (Murashige’s and Skoog) media, which stimulate shoots regeneration in different expl...
COLLOID MEDIATED DRUG TRANSPORT ACROSS DERMAL ROUTE: A CRITICAL REVIEW
Pressure techniques or Focussed forces like sonic pulses, voltage pulses, ballistic treatment or optoporation by Laser beam and use of penetration enhancers are more often invasive to overcome the multiple barrier functi...
COMPARATIVE LAXATIVE EVALUATION FOR ANDROGRAPHIS PANICULATA AND TERMINALIA CHEBULA IN EXPERIMENTAL ANIMAL MODEL
Crude aqueous extract of A.paniculata (family: Acanthaceae) and T.chebula (family: Combretaceae) at doses 100 and 200 mg/kg respectively were investigated for laxative activity according to Cappaso et al. in albino ra...
ROLE OF STRESS IN PATHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
Stress has been implicated as an important factor in the onset and exacerbation of wide array of disorders, from depression to irritable bowel syndrome. Stress results in the activation of hypothalamic pituitary axis (br...