COLLOID MEDIATED DRUG TRANSPORT ACROSS DERMAL ROUTE: A CRITICAL REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 4
Abstract
Pressure techniques or Focussed forces like sonic pulses, voltage pulses, ballistic treatment or optoporation by Laser beam and use of penetration enhancers are more often invasive to overcome the multiple barrier function of skin. Now, the colloidal systems are getting preference to be used transdermally. The colloidal systems include some basic structures like micelles, liposomes, nanoparticles, dendrimers, micro- and nanoemulsions etc. Again, for transdermal flux of any colloidal aggregate, the system must possess sufficient adaptability property depending upon the pore width, so to make a path way for its entry. The adaptability or deformability of the colloidal aggregate is a function of its composition. Micelles with long shape structures are flexible and depend upon binary phase composition. Vesicular or globular forms get the deformable nature by using lipid and membrane softener (bio surfactants) mixture. The diffusion or molecular barrier penetration of colloids need a driving force, which is provided by the trans-barrier hydration free energy gradient created internally or externally of and by the system. Some ultra deformable colloidal carriers like Transferosomes, Ethosomes, Aquasomes and Niosomes are potential systems for transport across the skin. However, this broad research area of colloids still needs much orientation and attention by researchers, rather than going for older invasive techniques.
Authors and Affiliations
Surendra Tripathy , Narahari Palei , Malay Das
Keywords
Related Articles
- EP ID EP147137
- DOI 10.7897/2230-8407.050450
- Views 102
- Downloads 0
DESIGNING OF COLON SPECIFIC MATRIX TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
The main aim of the study was to develop colon specific sustained release matrix tablets of diethyl carbamazine citrate (DEC), an anthelmintic for improving patient compliance, delivered to colon for its effective action...
DISORDERS RELATED TO NUCLEAR FACTOR KAPPA B ESSENTIAL MODULATOR (NEMO) IMMUNODEFICIENCY IN CHILDREN: A REVIEW
IKBKG is a gene that encodes for a protein which regulates nuclear factor kappa-B (NF-KB). This NF-KB not only plays an integral role in body’s inflammatory and immune responses but also affects ectodermal development....
MOUTH DISSOLVING FILM AND THEIR PATENT: AN OVERVIEW
Now days the researchers are focusing on the fast dissolving dosage form (FDDF’s).The fast dissolving dosage forms includes the mouth dissolving tablets, mouth dissolving thin films .The alternative words used for thes...
LIFE STYLE RELATED HEALTH HAZARDS
Our lifestyle is determined by our normal patterns of living. Life has become fast, ambitions and materialistic now-a-days. Routine day to day activities such as continuous use of Mobiles, long hours at computers/televis...
STANDARDIZATION AND ANTIMICROBIAL ACTIVITY OF FICUS RELIGIOSA LINN. (FAMILY: MORACEAE)
Ficus religiosa Linn. (Moraceae) has been traditionally claimed to be useful in asthmatic conditions, antidiarrhoeal, antiviral and astringent. It also shows antivenom activity. It is used in the treatment of various dis...