Abstract

 In present work was designed to develop suitable transdermal matrix patches of Lovastatin (LS),  using hydroxy propyl methyl cellulose (HPMC) and Eudragit RL 100 with Triethyl citrate as a plasticizer. A 32[/sup] full factorial design was employed, the amount of HPMC( X1[/sub]) and Eudragit RL- 100( X2[/sub]), was used as independent variables. The folding endurance, tensile strength, moisture content, moisture uptake and diffusion of drug were selected as dependent variables. The Casting solvent technique was employed for the preparation of HPMC, ERL-100 film. The dry films were evaluated for Physical appearance, thickness uniformity, moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 µ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at λ max 254 nm. The experimental results shows that the patch containing HPMC in higher proportion gives increase in the release of drug. It indicates that as the concentration of X2 (Eudragit RL 100) increase, the drug release from the matrix was decrease. The present study has demonstrated the potential of the fabricated matrix film for prolonged release of Lovastatin.

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