SCREENING OF ENDOPHYTIC FUNGI FROM CASSIA SIAMEA LAMK LEAVES AS α-GLUCOSIDASE INHIBITOR
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
Alpha glucosidase inhibitor is one of therapeutic approaches for diabetes mellitus which is known for its safety compare to other oral anti diabetic drugs. Therefore searching of α-glucosidase inhibitor from natural compounds was recently done by many researchers to find the new active compounds. Endophytic fungi have great potential as a source of α-glucosidase inhibitory compounds. This research aims to isolate the endophytic fungi from Cassia siamea Lamk. leaves and then to evaluate their α-glucosidase inhibitory activity. We successfully isolated five endophytic fungi colonies, and then each isolate was fermented and extracted with ethyl acetate and methanol. Each extract was assayed for its α-glucosidase inhibitory activity using spectrophotometry method. Nine extracts showed better α-glucosidase inhibitory than acarbose with the smallest IC50 value was 28.40 ppm.
Authors and Affiliations
Abdul Mun’im, M Ramadhan, Atiek Soemiati
Keywords
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- EP ID EP87498
- DOI 10.7897/2230-8407.04526
- Views 93
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