PREPARATION AND EVALUATION OF MUCOADHESIVE MICROCAPSULES OF IBUPROFEN FOR CONTROLLED RELEASE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
The aim of this study was to prepare and evaluate microcapsules containing ibuprofen employing sodium alginate in combination with mucoadhesive polymers namely methylcellulose, Hydroxypropylmethylcellulose and sodiumcaboxymethylcellulose. The microcapsules were prepared by orifice-ionic gelation method. The microcapsules prepared are spherical, discrete, free flowing and were of multinucleate and monolithic type. Microencapsulation efficiency was in the range of 77.81-91.41 %. The in vitro drug release of the microcapsules carried out in phosphate buffer pH7.2 and drug release from the microcapsules was slow over 12 h and depends on core:coat ratio, wall thickness and size of the microcapsules. The drug release from all the microcapsules followed non-fickian diffusion. Microcapsules of alginate- methylcellulose gave relatively fast release when compared to others. The order of release rate observed with various microcapsules was sodiumcaboxymethylcellulose < Hydroxypropylmethylcellulose < methylcellulose. Results of our present study suggest that ibuprofen microcapsules can be successfully designed to develop controlled drug delivery, which can improve compliance by reducing dosing frequency.
Authors and Affiliations
Appa Rao, M. R. Shivalingam, Y. V. Reddy, Sunitha Narla, V. Tejopavan
Keywords
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