Antiulcerogenic Activity on Aqueous Crude Extract of Emblica Officinalis Gaerth in Pylorus Ligated (Shay) Rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 4
Abstract
The complex and multifactorial pathogenesis of peptic ulcer has been studied over several decades, and results from an imbalance of aggressive gastric luminal factors acid and pepsin and defensive mucosal barrier function. Several environmental and host factors contribute to ulcer formation by increasing gastric acid secretion or weakening the mucosal barrier. Among environmental factors, smoking, excessive alcohol use, and drug use are most often quoted but none of them, apart from non-steroidal anti-inflammatory drugs (NSAID) use, were identified as an individual ulcerogenic agent. Emotional stress and psychosocial factors are frequently identified as important contributors to ulcer pathogenesis. Although stress cannot be neglected as a contributing factor, convincing evidence for it being the sole cause of duodenal ulcer is scarce. Aim of the present study is to evaluate the antiulcer activity of aqueous extract of Emblica officinalis (EO) on Pylorus ligated (Shay) rats model for ulcer. Additionally the muco protective effect also studied by aspirin-induced ulcerogenesis in pylorus ligated rats as the aqueous ethanolic extract reported as muco protective
Authors and Affiliations
Muthukumar A
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