AORTIC ATHEROSCLEROSIS AS A REFLECTION OF CORONARY ATHEROSCLEROSIS – AN AUTOPSY STUDY WITH HISTORICAL REVIEW
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 8
Abstract
Atherosclerosis is a disease which is worldwide and a major cause of morbidity and mortality. In the western world half of all deaths are attributable to this vascular disease. Studies have shown that the presence of severe atherosclerosis of thoracic aorta is associated with high mortality rate and strong predictor of coronary artery disease. Autopsy study which combines morphological details with case history collected especially regarding the risk factors for atherosclerosis can be a good method in understanding the disease process. Hence this autopsy study was undertaken to study atherosclerosis of aorta and coronary arteries to assess 1) the frequency of occurrence, 2) severity at different age and sex, 3) relation to the established risk factors like hypertension, diabetes mellitus and tobacco smoking, 4) to analyze the role of socioeconomic status and diet and 5) to compare the disease process between aorta and coronary artery of the same person. The severity of coronary atherosclerosis was less than aortic atherosclerosis upto the 5th decade. There was no significant variation after 6th decade in the incidence and also the severity of atherosclerosis between Aorta and coronaries. In 88.8% persons belonging to 5th decade showed grade III and IV lesions in aorta as against 33.3% had this type lesions in coronaries. In the 6th decade all the cases had both coronary and aortic involvement. 75% cases had grade III, IV lesions in aortas with similar lesions in 66.7% of coronaries. In 7th and 8th decade, severe degree lesions were seen in both aorta and coronaries. There was clear increased frequency of atherosclerosis associated with the major risk factors, hypertension, diabetes mellitus, tobacco smoking and older age. A similar study conducted by the same author two decades later proved this fact. There is an alarming increase in the number of deaths due to coronary atherosclerosis in India and this number is expected to escalate rapidly in the next decade.
Authors and Affiliations
Kusuma Venkatesh, Jayakeerthy C. M
Keywords
Related Articles
- EP ID EP222029
- DOI 10.18410/jebmh/2014/142
- Views 70
- Downloads 0
SINGLE INSTITUTIONAL EXPERIENCE IN SURGICAL MANAGEMENT OF ORBITAL TUMOURSNEUROSURGICAL PERSPECTIVE IN SURGICAL APPROACH
BACKGROUND Orbital tumours are rare and complex lesions, which require a multidisciplinary approach for diagnosis and management. They pose a great challenge for the neurosurgeons and ophthalmologists. MATERIALS AND METH...
COMPARISON OF AUTOMATED AND MERCURY BLOOD PRESSURE MEASUREMENT AMONG PREGNANT WOMEN IN RURAL HEALTHCARE SETTINGS
BACKGROUND Various kinds of error can arise during the process of blood pressure measurement and it is more with Mercury Sphygmomanometers (MM). Its comparability with the use of Automated Blood Pressure Measurement Devi...
LIMB LENGTH DISCREPANCY FOLLOWING CONSERVATIVE MANAGEMENT OF FEMORAL SHAFT FRACTURES IN CHILDREN, CLINICAL REVIEW AND RECOMMENDATIONS
BACKGROUND Shaft of femur is third most common location of fractures among children. In children there is strong potential for early union and remodeling even with conservative treatment. Conservative treatment is an acc...
STUDY OF LIPID PROFILE IN MALARIA- A PROGNOSTIC FACTOR
BACKGROUND Malaria is one of the most important parasitic infections human beings have ever known. Malaria is endemic in 91 countries with about 40% of world’s population at risk of acquiring the infection. Severe malari...
SIXTY YEARS AFTER INHALATIONAL DEVICES- WHERE DO WE STAND?
BACKGROUND Bronchial asthma and chronic obstructive pulmonary disease are the Common Respiratory Diseases (CRD’s). Drugs delivered through inhaler devices are the backbone for treatment of CRD’s. Inhaler technique errors...