Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes
Journal Title: Journal of Diabetes and Metabolic Disorders - Year 2012, Vol 11, Issue 0
Abstract
Background Apolipoprotein E (apo E) plays a major role in lipid metabolism, obesity and accordingly in development of diabetes and coronary heart disease (CHD). Our main objective was to evaluate the association between apo E gene polymorphism with anthropometric measures. Methods Participants were selected from zone 17 Tehran/Iran. We assessed height, weight, body mass index (BMI), waist circumference (WC), blood pressure, serum fasting blood sugar, total cholesterol and triglycerides. Genotyping for apo E gene polymorphism was carried out using PCR-RFLP technique. Results Among total study population (n=311), 156 subjects were diabetic. The apo E3/E3 was the most common genotype in our population while E2 and E4 alleles had lower frequencies, respectively. After adjustment for diabetes, the apo E2 and E4 alleles were significantly associated with hypercholesterolemia and WC, respectively (p= 0.009, 0.034). This association was also related to sex and age. The probability of having abdominal obesity in E4 allele carriers was increased from 0.22 to 8.12 in women and to 3.08 in age [greater than or equal to] 50 years. Conclusions Apo E polymorphism had significant influences on WC and total cholesterol level in patients with type 2 diabetes. This study highlights the importance of lifestyle modifications which may be more beneficial in hypercholesterolemic women carriers of E2 and E4 alleles concomitant central obesity.
Authors and Affiliations
Ozra Tabatabaei-Malazy, Hossein Fakhrzadeh, Mostafa Qorbani, Parvin Amiri, Bagher Larijani, Javad Tavakkoly-Bazzaz , Mahsa M Amoli
Keywords
Related Articles
- EP ID EP156194
- DOI -
- Views 90
- Downloads 0
Retraction: mobile phone text messaging and Telephone follow-up in type 2 diabetic patients for 3 months: a comparative study
This article (Zolfaghari M, et al., Metabolic Disorders 2012, 11:7) has been retracted as it has already been published in the Iranian Journal of Diabetes and Obesity (Zolfaghari M, et al., Iranian Journal of Diabetes an...
The importance of hypoglycemia in diabetic patients
Hypoglycemia is one of the most important complications of diabetes treatment. The risk of severe hypoglycemia is higher in elderly patients, those having comorbidities such as vascular disease or renal failure, pregnant...
Journal of diabetes and metabolic disorders: launch editorial
The high prevalence and great burden of diabetes and metabolic disorders are part of a growing problem of chronic disease predominance in the contemporary society. The World Health Organization has identified diabetes to...
Psychometric properties of the Iranian version of Diabetes Empowerment Scale (IR-DES-28)
Background This study was designed to determine the primary psychometric properties of the Iranian version of the Diabetes Empowerment Scale (IR-DES-28). Methods After translating the questionnaire into Persian, re-tr...
Development of an effective risk management system in a teaching hospital
Background Unsafe health care provision is a main cause of increased mortality rate amongst hospitalized patients all over the world. A system approach to medical error and its reduction is crucial that is defined by cl...