Apoptotic neuronal changes enhanced by zinc chelator - TPEN in organotypic rat hippocampal cultures exposed to anoxia
Journal Title: Folia Neuropathologica - Year 2006, Vol 44, Issue 2
Abstract
Both, the neurotoxic and neuroprotective effects of zinc have been well established, but the exact mechanism of its dual abilities still remains unclear. It has been shown that zinc deficiency leads to progressive neuronal injury. Therefore a safe zinc concentration levels seem to be necessary in neuronal protection from different noxious factors. This study was undertaken to determine the effect of zinc chelating agent – TPEN on neuronal morphological changes in organotypic hippocampal culture and its effect on post-anoxic changes in this model. The study evidenced that exposition to 15 µM of TPEN induced various stages of apoptotic changes in hippocampal pyramidal neurons and enhanced the anoxia-induced neuronal apoptosis in this model. These results confirmed the hypothesis that manipulations of intracellular pool of zinc by zinc-chelating agents may be a cause of both induction and prevention of apoptotic cell death in various pathological conditions.
Authors and Affiliations
Ewa Nagańska
Keywords
Related Articles
- EP ID EP82383
- DOI -
- Views 128
- Downloads 0
Materials from XIII Conference of Polish Association of Neuropathologists Warszawa, May 12-14, 2005 Original article The diagnosis and therapy of brain tumours
Neoplasms arising from glial cells make up the most common group of primary brain tumors. The clinical outcome, especially the survival rates of the patients with brain tumours depend on tumour grade expressing its mal...
Mononuclear subsets in the peripheral blood of multiple sclerosis patients in relation to results of brain gadolinium– enhancing imaging
Very little is known about processes which are leading to the development of new multiple sclerosis (MS) plaques. Therefore, the problem of correlating immunological disequilibrium in MS patients with the onset of a rela...
Autophagy – a basic mechanism and a potential role for neurodegeneration
Autophagy constitutes a fundamental survival strategy of cells; its disturbance contributes to the pathogenesis of cancer, liver and immune disease, pathogen infection, myopathies as well as neurodegenerative disorders s...
Frontotemporal dementia and parkinsonism linked to chromosome 17
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder caused by mutations in the MAPT gene which encodes the microtubule-associated protein tau....
Variant CJD (vCJD) and Bovine Spongiform Encephalopathy (BSE): 10 and 20 years on: part 1
From 1986 more than 184,000 cattle in the UK and islands (of which >1,880 have been detected by active surveillance using rapid tests) and approaching 5,500 elsewhere have been confirmed with BSE. The original 1988 ban o...