Apoptotic neuronal changes enhanced by zinc chelator - TPEN in organotypic rat hippocampal cultures exposed to anoxia
Journal Title: Folia Neuropathologica - Year 2006, Vol 44, Issue 2
Abstract
Both, the neurotoxic and neuroprotective effects of zinc have been well established, but the exact mechanism of its dual abilities still remains unclear. It has been shown that zinc deficiency leads to progressive neuronal injury. Therefore a safe zinc concentration levels seem to be necessary in neuronal protection from different noxious factors. This study was undertaken to determine the effect of zinc chelating agent – TPEN on neuronal morphological changes in organotypic hippocampal culture and its effect on post-anoxic changes in this model. The study evidenced that exposition to 15 µM of TPEN induced various stages of apoptotic changes in hippocampal pyramidal neurons and enhanced the anoxia-induced neuronal apoptosis in this model. These results confirmed the hypothesis that manipulations of intracellular pool of zinc by zinc-chelating agents may be a cause of both induction and prevention of apoptotic cell death in various pathological conditions.
Authors and Affiliations
Ewa Nagańska
Keywords
Related Articles
- EP ID EP82383
- DOI -
- Views 136
- Downloads 0
Is there a spatial association between senile plaques and neurofibrillary tangles in Alzheimer’s disease?
Obective: To test the hypothesis that the clusters of senile plaques (SP) and neurofibrillary tangles (NFT) in patients with Alzheimer's disease (AD) are spatially associated as predicted by the 'Amyloid Cascade Hypoth...
Chordoid meningiomas of a different histopathological pattern. A report of two cases
Chordoid meningioma is an uncommon histopathological variant of meningioma with a peculiar chordoma-like appearance. Its association with systemic inflammatory disorder linked to Castleman’s syndrome was confirmed in the...
Multiple mononeuropathy due to vasculitis associated with anticardiolipin antibodies: a case report
This report illustrates a case of peripheral nerve vasculitis associated with elevated anticardiolipin antibodies. A 49-year-old female with a history of seven spontaneous abortions initially complained of pain and numbn...
Immunohistochemical expression of progesterone and estrogen receptors in meningiomas
In this study we present results of investigations of progesterone and estrogen receptors in most frequent, WHO grade I histological types of meningiomas (meningothelial, fibrous, and transitional) and in atypical – WHO...
1st Conference of Polish-German Cooperation Program in Neuroscience ordered by the Federal Ministry of Education and Research and the Polish Ministry of Education and Science April 21-22, 2006 in Warsaw, Poland