Multiple mononeuropathy due to vasculitis associated with anticardiolipin antibodies: a case report
Journal Title: Folia Neuropathologica - Year 2006, Vol 44, Issue 2
Abstract
This report illustrates a case of peripheral nerve vasculitis associated with elevated anticardiolipin antibodies. A 49-year-old female with a history of seven spontaneous abortions initially complained of pain and numbness in her right calf that later spread to the left foot and ankle. Over the next few months, she developed a Raynaud phenomenon and livedo reticularis. Clinical examination revealed signs of multiple mononeuropathy. Right sural nerve biopsy performed two months after the beginning of the disease revealed active necrotizing arteritis of the epineural arteries with transmural inflammatory infiltrate and thrombosis. Vasculitis is a rare finding in sural nerve biopsies, usually in patients with systemic vasculits or autoimmune connective tissue diseases. However, vasculitis restricted to the peripheral nerves has also been described. Our patient had no clinical or laboratory features of any autoimmune disorder and also no signs of systemic vasculitis. We discuss the potential role of anticardiolipin antibodies in the pathogenesis of vasculitis.
Authors and Affiliations
Jera Jeruc, Mara Popović, Alenka Vizjak, Vesna Jurčić, Boris Lestan, Dušan Ferluga
Keywords
Related Articles
- EP ID EP154607
- DOI -
- Views 97
- Downloads 0
Leukoencephalopathy with vanishing white matter due to homozygous EIF2B2 gene mutation. First Polish cases
Leukoencephalopathy with vanishing white matter (VWM), also called childhood ataxia with central nervous system hypomyelination (CACH), is an autosomal recessive disease caused by mutations in any of the five genes encod...
Variant CJD (vCJD) and Bovine Spongiform Encephalopathy (BSE): 10 and 20 years on: part 2
Up until February 2006, variant CJD (vCJD), the human disease associated with transmission of BSE from cattle, has been confirmed in 160 patients resident in the UK and 28 elsewhere, some of whom have never visited the U...
Autophagy – a basic mechanism and a potential role for neurodegeneration
Autophagy constitutes a fundamental survival strategy of cells; its disturbance contributes to the pathogenesis of cancer, liver and immune disease, pathogen infection, myopathies as well as neurodegenerative disorders s...
Materials from XIII Conference of Polish Association of Neuropathologists Warszawa, May 12-14, 2005 Original article The diagnosis and therapy of brain tumours
Neoplasms arising from glial cells make up the most common group of primary brain tumors. The clinical outcome, especially the survival rates of the patients with brain tumours depend on tumour grade expressing its mal...
Ultrastructural study of cerebellar dentate nucleus astrocytes in chronic experimental model with valproate
The current study focuses on the morphogenesis of changes in the cerebellum dentate nucleus in the course of experimental valproate encephalopathy. Valproate – a broad spectrum antiepileptic and antipsychotic drug – chro...