Application of ETDRS chart and mfERG in assessing pathologic myopia combined with macular CNV after treatment
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 7
Abstract
AIM:To evaluate the efficacy of anti- vascular endothelial growth factor(VEGF)and photodynamic therapy(PDT)on pathological myopia(PM)combined with choroidal neovascularization(CNV)using ETDRS chart and multifocal electroretinogram(mfERG). <p>METHODS: Forty-three patients(45 eyes)diagnosed by fundus fluorescein angiography(FFA), indocyanine green angiograph(ICGA)and optical coherence tomography(OCT)with PM combined with macular CNV were recruited in this study. The patients were randomly divided into two groups for different treatments, intravitreal injection with Ranibizumab(20 patients, 22 eyes)and PDT(23 patients, 23 eyes). After treatment, all patients had been followed up monthly for 12mo. The further treatments were operated according to referral situations. The best corrected visual acuity(BCVA)was recorded with the ETDRS chart and mfERG. At the last follow-up, the therapy efficacy was determined by ETDRS numbers and mfERG and analyzed. <p>RESULTS:Before treatment, there was no significant difference on the baseline in ETDRS and mfERG latency of N1 wave, latency and the density values of P1 wave between ranibizumab group and PDT group. After 12mo treatment, the ETDRS number in ranibizumab group(39.23±20.06)significantly increased to the baseline by 5.88±9.03(<i>P</i><0.05), and in PDT group(37.38±16.95)was not significantly improved by 0.33±6.94(<i>P</i>>0.05). There was no significant difference in latency of N1 wave, latency and the density values of P1 wave from treatment response of mfERG in the two groups(<i>P</i>>0.05). <p>CONCLUSION: In the treatment of macular CNV complicated by the PM, ranibizumab injection can improve visual function better than PDT, while similar on macular.
Authors and Affiliations
Jing Yan
Keywords
Related Articles
- EP ID EP553702
- DOI 10.3980/j.issn.1672-5123.2018.7.26
- Views 128
- Downloads 0
Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema
AIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from F...
EDI-OCT detecting retinal and choroidal thickness in patients with pregnancy induced hypertension
AIM: To observe and compare the changes of foveal retinal and choroidal thickness in patients with pregnancy-induced hypertension(PIH)by enhanced depth imaging optical coherence tomography(EDI-OCT). <p>METHODS: Totally 1...
The 24- hour pattern of intraocular pressure in suspected glaucoma patients
AIM: To analyze the value of 24-hour intraocular pressure(IOP)monitoring in suspected glaucoma patients.<p>METHODS: Totally 48 suspected glaucoma(96 eyes)were selected for 24-hour IOP monitoring by using Accupen tonomete...
Corneal aberrations in normal and keratoconic eyes using an OPD-Scan Ⅱ
AIM: To evaluate higher order aberrations(HOAs)of the corneal surface in normal and keratoconic eyes.<p>METHODS: Using an OPD-Scan Ⅱ wavefront analyzer, aberrometric parameters of the corneal surface in one eye of 80 pat...
Comparison of IOP detected by three kinds of tenonometers in children with high intraocular pressure and their relations with corneal thickness
AIM: To investigate the central corneal thickness(CCT)distribution of the children with ametropia in the non-contact tonometry(NCT), and the different intraocular pressure(IOP)measurements with Goldmann applanation tonom...