Application of OLGA (Operative link on gastritis assessment) staging system for gastritis in alcoholics- a cross sectional study
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 3
Abstract
Introduction Gastritis is an inflammatory condition of the gastric mucosa Atrophy of the gastric mucosa is the endpoint of chronic processes such as chronic gastritis associated with H pylori infectionCurrently no reporting schemeterminology for chronic gastritis is available that is both easily understood by clinicians and patients and also provides prognostic and therapeutic information in unequivocal termsAn international group Operative Link on Gastritis Assessment OLGA proposed a staging system for reporting gastric histology This gastritis staging integrates the atrophy score obtained by biopsy and the atrophy topography achieved through directed biopsy mappingThis prospective crosssectional study aimed to apply the OLGA staging system for reporting gastric histology in alcoholic patients with gastritis thus validate the OLGA gastritis staging system as a routine histology reporting systemMaterials and Methods A prospective study was conducted from October 2013 to June 2015 in the Department of Gastroenterology MS Ramaiah Hospitals MS Ramaiah Teaching Hospital and MS Ramaiah Memorial Hospital Bangalore 150 alcoholic patients were involved in the study Age sex presenting complaints and detailed history regarding alcohol intake was taken followed by investigations like Complete Blood Count Liver Function Tests Renal Function Tests and ultrasound abdomen Patients were categorised clinically into 4 groups as Alcohol Dependence Syndrome ADS fatty liver Compensated Liver Disease CLD and Decompensated Liver Disease DCLD Rapid urease test was done for all the patients and 5 biopsy samples 2 from antral mucosa 2 from oxyntic area and one from the mucosa of the incisura angularis were obtained and sent to the pathology department Sections made from these gastric biopsies were stained with H and E and Giemsa stain Sections were then evaluated for the presence of H pylori Severity of atrophic gastritis was noted and finally OLGA scoring was given for each patientResults In the 150 alcoholic patients included in the study prevalence of H pylori was 76 The age and the gender did not play a role in the H pylori infectionADS constituted 53 patients 353 Fatty liver 21 14 CLD 39 26 DCLD 37 247 H pylori prevalence was 604 714 821 and 946 respectivelyWith the increase in OLGA staging number of H pylori positive patients increased which is statistically significant p value is Majority of the patients with ADS belonged to OLGA stage 0 37 cases 698 and majority of the patients with DCLD belonged to OLGA stage II 26 cases 703 The current study revealed that the OLGA staging increased with worsening of the ALDConclusion The OLGA staging increases as the clinical presentation of ALD worsens With the increase in OLGA staging number of H pylori positive patients increased The new OLGA staging system proved easy to use and provides clear prognostic informationKeywords H pylori OLGA Alcohol intake ALD
Authors and Affiliations
Rakshitha HB, Nandini GV, Mangala Gouri, Avinash Balekuduru
Keywords
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- EP ID EP482775
- DOI 10.18231/2581-3706.2018.0043
- Views 108
- Downloads 0
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