Application of peripheral nerve invasion based nomogram model in predicting the prognosis of stage Ⅰ-Ⅲ early-onset colorectal cancer
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9
Abstract
Objective To evaluate the impact of peripheral nerve aggression (PNI) on prognosis in patients with stage Ⅰ-Ⅲ early-onset colorectal cancer (EO-CRC) and to create a PNI-based nomogram prediction model. Methods This study analyzed data on 5 920 EO-CRC patients aged 50 years and younger enrolled in the U.S. Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. The patients were divided into the training group (n=4 164) and the validation group (n=1 756) by a ratio of 7∶3. Kaplan-Meier survival curve was drawn and Cox proportional risk model was used for univariate and multivariate prognosis analysis. Based on the significant variables of the multivariate model, a nomogram was constructed, and the predictive ability was evaluated by receiver operating characteristic curve (ROC), calibration curve and decision curve analysis (DCA). Results Compared with PNI negative patients, PNI positive patients tended to be young, lesions located in the left colon, with poorer differentiation, higher TNM stage, chemotherapy intervention, and higher CEA level (P＜0.05). Kaplan-Meier curve suggested that PNI positive group had a worse prognosis than PNI negative group. Cox univariate analysis suggested that age, sex, degree of tumor differentiation, TNM stage, T stage, N stage, whether to receive radiation therapy, whether to receive chemotherapy, CEA level, maximum tumor diameter and PNI status were variables affecting the survival and prognosis of patients. Multivariate analysis showed that PNI was an independent prognostic indicator for patients with stage Ⅰ to Ⅲ EO-CRC (HR=1.73, 95%CI: 1.44-2.08, P＜0.01). The area under ROC curve of nomogram model based on PNI was more than 0.7 in both 3-year and 5-year lifetime. Conclusion PNI can be used as an independent prognostic marker in patients with stage Ⅰ-Ⅲ EO-CRC, and PNI-based nomogram model can be used as an effective prognostic tool.
Authors and Affiliations
ZHU Juntao, LIU Lei, YAO Jianan, WU Jie, PENG Anyi, JI Guozhong
Keywords
Related Articles
- EP ID EP745456
- DOI 10.13429/j.cnki.cjcr.2024.09.009
- Views 1
- Downloads 0
Research progress of fibroblast growth factor receptor in gastric cancer
The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very lo...
Correlation between triglyceride-glucose index and atherosclerosis in type 2 diabetes mellitus
Objective To investigate the the clinical application of triglyceride-glucose (TyG) index and its correlation with atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Methods From January 2020 to December...
Research progress in sensitivity to inhalation anesthetics
Inhalation anesthetics have both sedative, analgesic and muscle relaxing effects,and are widely used in clinical practice. Hypersensitivity to inhalation anesthetics predicts poor postoperative outcomes. Current studies...
Research progress on the clinical application of PCSK9 inhibitors in coronary heart disease
Coronary heart disease (CHD) is currently an important cause of mortality among residents in China and worldwide. The incidence of CHD in China is increasing annually. Among the various factors leading to the occurrence...
Incidence and risk factors of calf muscular venous thrombosis in patients with severe acute ischemic stroke in NICU
"<b>Objective</b> To investigate the incidence of calf muscular venous thrombosis (CMVT) and analyze its risk factors among patients with severe acute ischemic stroke (AIS) in the Neurological Intensive Care Unit (NICU)...