Application of quality by design paradigm in the design of muco-adhesive extended release film for oral ulcer
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2018, Vol 3, Issue 2
Abstract
The present study deals with the formulation of mucoadhesive bilayered buccal film of lidocaine hydrochloride and benzydamine hydrochloride for treatment of oral ulcers aphthous stomatitis EudragitRLPO and Ethyl cellulose were used asfilm forming polymers and low viscosity grade hydroxyl propyl cellulose as a mucoadhesive agent Solvent casting method was adopted for film formation The film was evaluated for content uniformity tensile strength folding endurance swelling mucoadhesive strength ex vivo mucoadhesive time and in vitro drug release The films were characterized for DSC and FTIR The film showed acceptable film properties and mucoadhesion The formulation showed predictive drug release ie 80 in 2 4 and 6 h respectively Invitro drug release study revealed that a combination of Eudragit and Ethyl cellulose was required for better control of the drug release The DSC and FTIR study confirmed drugdrug and drugexcipient compatibilityKeywordsBilayer film EudragitRLPO Ethyl cellulose Mucoadhesion Extended drug release
Authors and Affiliations
Manali Prajapat, Kunal Parmar, Shital Bhutani, Rajesh Parikh, Toral Patel
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Application of quality by design paradigm in the design of muco-adhesive extended release film for oral ulcer
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