APPLICATIONS OF GOLD NANOPARTICLES IN CLINICAL MEDICINE

Abstract

Gold based nanoparticles, owing to their unique optical properties at the nanoscale, biocompatibility, and rich surface chemistry, have attracted considerable attention from the material science and biomedical community. Although colloidal gold has been used since ancient times in various therapeutic applications, a better understanding of the physical attributes of nanosized gold has led to a burst of research activity in the past twenty years related to their synthesis and biomedical applications. Novel strategies for the synthesis of nanosized gold of various shapes and morphologies have been put forward, which includes nanospheres, nanorods, nanocages, nanoshells, etc. Both the absorption and scattering properties of nanosized gold, along with their facile conjugation with different biomolecules, has been exploited in the development of a number of bioanalytical assays and protocols, related to the quantification of nucleic acids, proteins, other small biomolecules, etc. In addition, gold nanoparticles are being increasingly used for in vivo imaging applications for the early diagnosis of cancer. Finally, gold nanoparticles are playing a significant role in nanotherapeutic applications, either as drug carriers or as the drug itself in light-activated photothermal therapy. Several gold-nanoparticle based Bioanalytical assays and therapeutic applications are in the active clinical development phase. This chapter will provide examples of the various biomedical applications of gold nanoparticles with potential for clinical translation.Keywords: Gold nanoparticles, Theranostics, SPR, Colorimetric biosensing, SERC, In vitro diagnostics, PTT, PDT

Authors and Affiliations

Pramod Kumar, Indrajit Roy

Keywords

Related Articles

COMBINATIONAL EFFECTS OF ETHYLACETATE EXTRACT OF PICRIA FEL-TERRAE LOUR AND DOXORUBICIN ON T47D BREAST CANCER CELLS

Objective: To evaluate the effects of ethyl acetate extract (EAE) of Picria fel-terrae Lour. Leaves and combination with doxorubicin on cytotoxicity, cell cycle, apoptotis and suppression of cyclin D1 and Bcl-2 express...

IMPACT OF PROLONGED REDUCED-PRESSURE CONDITION PRIOR TO PRECURSOR LABELING ON THE LABELING EFFICIENCY OF F-18 FLUOROCHOLINE SYNTHESIS

Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this...

IDENTIFICATION OF LEAD COMPOUNDS WITH COBRA VENOM DETOXIFICATION ACTIVITY IN ANDROGRAPHIS PANICULATA (BURM. F.) NEES THROUGH IN SILICO METHOD

Objective: To validate the cobra venom detoxification activity in Andrographis paniculata and identification of lead molecules.Methods: The structures of phytochemicals were procured from databases or created by ChemSket...

MESOIONIC SYDNONE: A REVIEW IN THEIR CHEMICAL AND BIOLOGICAL PROPERTIES

Various literature sources have documented sydnones as important molecules with exclusive chemical properties and a wide spectrum of bioactivities. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic m...

DETERMINATION OF INDONESIAN NATIVE STINGLESS BEE PROPOLIS AS COMPLEMENTARY NUTRACEUTICAL CANDIDATE OF ANTI-TUBERCULOSIS DRUG

Objective: This study aimed to determine Indonesian native stingless bee propolis from ten provinces of Indonesia as complementary nutraceutical candidate of anti-tuberculosis drug (ATD).Methods: Propolis samples were co...

Download PDF file
  • EP ID EP576203
  • DOI -
  • Views 65
  • Downloads 0

How To Cite

Pramod Kumar, Indrajit Roy (2016). APPLICATIONS OF GOLD NANOPARTICLES IN CLINICAL MEDICINE. International Journal of Pharmacy and Pharmaceutical Sciences, 8(7), 9-16. https://europub.co.uk/articles/-A-576203