APPLICATIONS OF GOLD NANOPARTICLES IN CLINICAL MEDICINE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Gold based nanoparticles, owing to their unique optical properties at the nanoscale, biocompatibility, and rich surface chemistry, have attracted considerable attention from the material science and biomedical community. Although colloidal gold has been used since ancient times in various therapeutic applications, a better understanding of the physical attributes of nanosized gold has led to a burst of research activity in the past twenty years related to their synthesis and biomedical applications. Novel strategies for the synthesis of nanosized gold of various shapes and morphologies have been put forward, which includes nanospheres, nanorods, nanocages, nanoshells, etc. Both the absorption and scattering properties of nanosized gold, along with their facile conjugation with different biomolecules, has been exploited in the development of a number of bioanalytical assays and protocols, related to the quantification of nucleic acids, proteins, other small biomolecules, etc. In addition, gold nanoparticles are being increasingly used for in vivo imaging applications for the early diagnosis of cancer. Finally, gold nanoparticles are playing a significant role in nanotherapeutic applications, either as drug carriers or as the drug itself in light-activated photothermal therapy. Several gold-nanoparticle based Bioanalytical assays and therapeutic applications are in the active clinical development phase. This chapter will provide examples of the various biomedical applications of gold nanoparticles with potential for clinical translation.Keywords: Gold nanoparticles, Theranostics, SPR, Colorimetric biosensing, SERC, In vitro diagnostics, PTT, PDT
Authors and Affiliations
Pramod Kumar, Indrajit Roy
Keywords
Related Articles
- EP ID EP576203
- DOI -
- Views 78
- Downloads 0
BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS
Objective: The main aim of this study was to design and characterise betamethasone di-propionate loaded transfersomes (BD-T); as a topical formulation for the treatment of localized plaque psoriasis.Methods: A full facto...
ANTI-INFLAMMATION EFFECTS OF BIOACTIVE FRACTION DLBS0533 CONTAINING PHALERIA MACROCARPA AND NIGELLA SATIVA ON ANIMAL MODEL
Objective: Â DLBS0533 extract is a bioactive fraction obtained from combination of Phaleria macrocarpa and Nigella sativa. This present study aims to observe its potentially anti-inflammatory activities using carragenaan...
STUDY ON DRUG UTILIZATION PATTERN OF CHRONIC RENAL FAILURE PATIENTS IN A TERTIARY CARE HOSPITAL
Objective: Chronic Renal Failure is a worldwide public health problem with an increasing incidence and prevalence, poor outcomes and high cost of treatment due to co-morbidities and Polypharmacy. The aim of this study wa...
SIMULTANEOUS ESTIMATION OF PROPAFENONE AND ITS TWO METABOLITES IN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY LC-MS/MS
Objective: A simple, sensitive and rapid performance liquid chromatography/positive ion electrospray tandem mass spectrometry method was to be developed and validated for quantification of propafenone (PPF) and its two m...
EFFECT OF FUCITHALMIC AND SOFINOX EYE DROPS ON EXPERIMENTAL ALLERGIC CONJUNCTIVITIS IN RATS
Objective: To investigate the therapeutic effect of Fucithalmic 1%, Sofinox 0.5% and 1% eye drops against an IgE-mediated allergic conjunctivitis model in Wistar rats.Methods: IgE-mediated allergic conjunctivitis was ind...