Applications of K +channel modulators in clinical practice: Review
Journal Title: Applied Physiology and Anatomy Digest - Year 2016, Vol 1, Issue 3
Abstract
Ion channels present in plasma membrane & intracellular organelles of all cells play an important role in maintaining cellular integrity, smooth muscle contraction, secretion of hormones & neurotransmitters. Among these K + channels are the most abundant having important role in cardiac repolarization, smooth muscle relaxation, gastrointestinal peristalsis & insulin release etc. K +channels are grouped into families based on their structures as well as physiological & pharmacological criteria. The opening & closing of K + channels are modulated by many compounds like ATP, ADP, and Nitric oxide. Channel modulators are the substances which modulate the opening or closing of channels. There are number of methods like electrophysiological, Biochemical, Animal experiments to study these ion channels & channel modulators. K + channels are associated with diseases like Diabetes, epilepsy & long QT syndrome etc. The diverse nature of K + channels offers the opportunity for new drug development. This review covers such methods with their conclusion & tries to highlight the importance of application of K + channel modulators in clinical practice.
Authors and Affiliations
Dr Motilal C Tayade
Keywords
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