Applications of K +channel modulators in clinical practice: Review
Journal Title: Applied Physiology and Anatomy Digest - Year 2016, Vol 1, Issue 3
Abstract
Ion channels present in plasma membrane & intracellular organelles of all cells play an important role in maintaining cellular integrity, smooth muscle contraction, secretion of hormones & neurotransmitters. Among these K + channels are the most abundant having important role in cardiac repolarization, smooth muscle relaxation, gastrointestinal peristalsis & insulin release etc. K +channels are grouped into families based on their structures as well as physiological & pharmacological criteria. The opening & closing of K + channels are modulated by many compounds like ATP, ADP, and Nitric oxide. Channel modulators are the substances which modulate the opening or closing of channels. There are number of methods like electrophysiological, Biochemical, Animal experiments to study these ion channels & channel modulators. K + channels are associated with diseases like Diabetes, epilepsy & long QT syndrome etc. The diverse nature of K + channels offers the opportunity for new drug development. This review covers such methods with their conclusion & tries to highlight the importance of application of K + channel modulators in clinical practice.
Authors and Affiliations
Dr Motilal C Tayade
Keywords
Related Articles
- EP ID EP552737
- DOI -
- Views 144
- Downloads 0
Study of Variantions of Posterior Cerebral Circulation and its Clinical structural Relevance : Cadaveric study
Introduction: Cerebrovascular diseases such as stroke, aneurysms and arterio-venous malformations are very much prevalent in our country. Circle of Willis, as an anastomotic polygon at the base of the brain forms an impo...
A Cross-sectional study of anatomical variations in the splenic artery branches
Background: The knowledge of branching pattern of splenic artery, different levels of its division and their measurements, especially lobar artery, segmental artery, trabecular artery and polar artery is very important f...
A prospective study of association of type 2 diabetes in family history of hypertension
Introduction:The incidenceof diabetes mellitus is rapidly increasing worldwide, including in Asian countries. This disease contributes to many complications and comorbidities, including diabetic retinopathy leading to im...
A study of serum lipid profile in undernourished patients of diabetes mellitus
Background & objective: The incidence of diabetes mellitus is increasing substantially worldwide. The latest estimates by the international diabetes federation project that 592 million (1 in 10 persons) worldwide will ha...
Study of variations in the Arcuate artery
Introduction: Arcuate artery is branch of Dorsalis pedis artery which supplies web spaces through its branches. Position and distribution of Arcuate artery is imperative to surgeons. The study was planned to know the va...