A prospective study of association of type 2 diabetes in family history of hypertension
Journal Title: Applied Physiology and Anatomy Digest - Year 2018, Vol 3, Issue 3
Abstract
Introduction:The incidenceof diabetes mellitus is rapidly increasing worldwide, including in Asian countries. This disease contributes to many complications and comorbidities, including diabetic retinopathy leading to impaired vision, renal failure leading to hemodialysis, and cardiovascular accidents. These conditions lead to impairments in the quality of life of patients and create a large financial burden for health care systems. Materials and Methods:This study was conducted in department of Physiology, the study was conducted at Osmania Medical College & Hospital, Hyderabad from January 2017 to December 2017. The criteria used for the diagnosis of diabetes were defined by the Japan Diabetes Society; these criteria are almost identical to the criteria of the World Health Organization. The presence or absence of a self-reported family history of diabetes and hypertension of the individual’s grandparents, parents, siblings, children, or grandchildren was obtained from medical records and was entered into the database. Results:In the present study, the patient age at the time of the diagnosis of diabetes was lower in the group with a positive family history of diabetes (47.6 ± 8.3 years; n = 652) than in the group with a negative family history of diabetes (52.6 ± 11.4 years; n = 490; p < 0.001, Table 2) and was also lower in men (mean ± SD, 49.4 ± 10.8 years; n = 1,021) than in women (mean ± SD, 53.6 ± 11.2 years; n = 278; p < 0.001). Accordingly, we performed a multivariable linear regression analysis using the presence or absence of a family history of hypertension, the presence or absence of a family history of diabetes mellitus, and sex as independent variablesand the patient age at the time of the diagnosis of type 2 diabetes as the dependent variable. In this model, these three independent variables all significantly affected the patient age at the time of the diagnosis of type 2 diabetes. Next, we added interaction terms to the regression model, but no significant interaction effect was observed. Conclusion:The findings of the present prospective study suggest that a positive family history of hypertension might be associated with an accelerated onset of type 2 diabetes. Subjects with a family history of hypertension should be informed of their personal risk at an early age accompanied by information on preventive health behaviors to reduce their chances of ever developing type 2 diabetes.
Authors and Affiliations
C. Saroja, Kondam Ambareesha
Keywords
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