Applying Cox Proportional Hazards Model to Identifying the Factors Affecting the Survival of Patients with Brain Metastasis
Journal Title: The Journal of Tolooebehdasht - Year 2017, Vol 16, Issue 1
Abstract
Introduction: The aim of this study is to determine of risk factors in patients with brain metastases, and prognostic factors affecting survival of patients by using the Cox proportional hazards model. Methods: This descriptive - analytic retrospective study was performed on 197 patients with brain metastases who referred to Shahid Ramezanzadeh Radiation Center, Yazd, Iran. Several risk factors in these patients were analyzed by the Cox model. Survival times were estimated by Kaplan - Meier and significant difference between the survivals distributions of sub groups were compared with the log-rank test. The data were analyzed by R and SPSS soft wares. Results: The Kaplan-Meier estimate of patients overall survival were 27% at 12 months and 12% at 24 months. By the log - rank test we founded that there was significant difference between the patients survival in subgroups of variables, such as: age at diagnosis, outside brain diseases (primary tumor), type of treatment, response to radiotherapy and re-radiation therapy (P<0.05). Cox model analysis indicated that the survival of patients with brain metastases influenced by the outside brain diseases (primary tumor) and response to radiotherapy variables. Conclusion: According to this result, control of the primary tumor and appropriate by radiation therapy seems to be effective to increase patients Lifetime. Also, it is more appropriate to use the Cox model in medical studies because of its easy for interpretation and not limited to use the type of covariates.
Authors and Affiliations
Mohsen Asgari Shahi, Homa Moazen, Ali Akhavan, Fariba Binesh
Keywords
Related Articles
- EP ID EP261036
- DOI -
- Views 101
- Downloads 0
Impact of Banking Development on CO2 Emissions in Iran
Introduction: Identifying the effect of energy consumption, economic growth and foreign trade on CO2 emissions have been studied at both national and international levels. However, there have been very few researches on...
Investigation on Industrial Waste Waters Reuse of Industrial Towns for Agricultural and Irrigation Uses (Case Study: Treatment Plant of Jahan Abad MeybodIndustrial Town)
Introduction: With attention to the existence numerous numbers of industrial towns and them volume of generated wastewater and problems of shortage of water in the Yazd province, therfore the proper wastewater treatment...
Determinants of Health Behaviors among Air Travelers of Shiraz Shahid Dastghaib International Airport based on Health Belief Model
Introduction: Health is also particularly important in flights. The current study aimed to investigate the determinants of health behaviors among travelers of Shiraz Shahid Dastghaib International Airport based on Health...
Application of Coagulation and Flocculation Coupled with Photo Catalytic Degradation (TiO2/UV- A) for 2- (Methoxy Carbonyl
Introduction:Effluents contains dyes Because of the adverse health effects of Environmental and dangerous for public health. The aim of this study was to the use of a combination coagulation and flocculation process Coup...
Prevalence and Antibiotic Resistance of Listeria Monocytogenes in Different Stages of Poultry Slaughter and Poultry Slaughterhouse Environment, Yazd, Iran, 2015
Introduction: Listeria monocytogenes is an important psychrotrophic foodborne pathogen that exists in poultry meat and causes listeriosis with severe clinical consequences such as meningitis, septicemia, and abortion. Th...