Aqueous Extract of Juglans Nigra Prevents Lead Induced Testicular Toxicity in Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2010, Vol 3, Issue 3
Abstract
Background. Lead is a heavy metal that has been known for its adverse effects on many body organs and systems and thus their functions. Aim. In this study, the toxic effect of lead on the testicular system was investigated, and Aqueous Extract of Juglans Nigra (JnE) (a well known antioxidant) was administered orally to prevent this effect. Materials and Methods. Twenty-four adult male Wister rats, randomly divided into four groups (n = 6), were used for this study. Group B and Group D were given 3g of JnE/Kg Body Weight/Day (orally) and 1% sodium acetate and Lead acetate respectively, while group A (control) and group C were given sodium acetate and lead acetate respectively. All treatments were for eight weeks. The animals were sacrificed twenty-four hours after the last treatment. Sperm count, motility, morphology, and testosterone level were determined. The control and “test†groups were compared using independent-sample ttest. Results. The results obtained showed that lead caused a significant decrease in epididymal weight, sperm count, sperm mortility and testosterone level; and significant increase in abnormal structure of spermatozoa. These (abnormalities) were however, prevented in the JnE treated groups. Conclusion. It is therefore concluded that oral admistration of JnE promote fertility and annuls lead induced testicular texicity.
Authors and Affiliations
Abdul Alhassan| Ahmadu Bello University, Department of Human Physiology, Zaria, Kaduna State, Nigeria, Mohamed Mabrouk| Ahmadu Bello University, Department of Human Physiology, Zaria, Kaduna State, Nigeria, Ramatu Idris| Ahmadu Bello University, Department of Human Physiology, Zaria, Kaduna State, Nigeria, Emmanuel Salawu| Ladoke Akintola University of Technology, Department of Physiology, Ogbomoso, Oyo State, 234038, Nigeria, Abiodun Oyerinde| Ladoke Akintola University of Technology, Department of Physiology, Ogbomoso, Oyo State, 234038, Nigeria, Zainab Bauchi| Ahmadu Bello University, Department of Human Physiology, Zaria, Kaduna State, Nigeria
Keywords
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- EP ID EP8758
- DOI 10.3889/MJMS.1857-5773.2010.0109
- Views 404
- Downloads 23
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