Adverse Effects of Organophosphorus Insecticides on Macrophage Activity in Persons at High Risk for Parasitic Infection
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 3
Abstract
Background: It has been suggested that acute exposure to pesticides altered the ability of macrophages to overcome the pathogen invasion. Aim: To evaluate the levels of NO, IFN-gamma and arginase in both rats and patients with cutaneous leishmaniasis (CL) exposed daily to the chlorpyrifos (CPF) pesticide. Also, to evaluate the benefits of curcumin and / or arginine as a prophylactic agents. Materials and Methods: Plasma samples from 25 CL patients, 10 healthy control and CPF-treated rats, divided into five groups, were extracted. Also, PBMNCs recruited only from CL patients. Results: A significant increase in the level of arginase coupled with a significant decrease in the levels of NO and INF-gamma were observed in CPF-treated animals. Restoration of the previous biochemical markers were significantly observed when a mixture of curcumin and arginine was used as a prophylactic remedy. In CL patients, a significant increase in the level of arginase activity was noticed. However, when curcumin is added to the cultural media containing active PBMNCs recruited from CL patients, a significant decrease in the level of NO associated with an increase in the arginase levels were noticed. Conclusion: The negative effect of CPF on macrophage activity can be attenuated by oral intake a mixture of curcumin and arginine.
Authors and Affiliations
Magdi Nabih Ashour| National Research Centre, Medical Biochemistry, Al-tahrir Street, Dokki-Geza, Cairo 12311, Egypt, Mohamed Essa Mohamed| Faculty of Medicine, Zagazig University - Clinical Pathology and Hematology, Zagazig, Egypt, Bassem Mohamed Elsawy| Faculty of Medicine, Cairo University - Anatomy, Cairo, Egypt
Keywords
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- EP ID EP8812
- DOI 10.3889/MJMS.1857-5773.2011.0143
- Views 346
- Downloads 17
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