Are HIV-Infected Patients from Low Socioeconomic Conditions at Risk of Gastritis due to Helicobacter Pylori

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Are HIV-Infected Patients from Low Socioeconomic Conditions at Risk of Gastritis due to Helicobacter Pylori

Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 2

Abstract

Background: This study conducted in a mining town in Matebeleland South Zimbabwe evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients coming from a low socioeconomic background. Methods: Blood samples were collected from 110 patients, who came to healthy centres complaining of gastritis. H. pylori status and HIV status were serologically screened on these samples. Results: The prevalence of H. pylori infection was significantly lowers (p < 0.001) in HIV-infected (37.2% males and 30% females) than in uninfected (75.8% males and 70% females) for patients. There were no significant differences between H. pylori status and gender. Ante retroviral treatment, Viral Load and CD4 assessments were not done on this group of patients. Conclusion: We demonstrated that the prevalence ofH. pylori was significantly lower in HIV-positive patients compared with HIV-negative ones. However, gastritis was frequently observed in the HIV-positive patients as it was their major reason for coming to the clinics. t is well known that the immune deficiencies caused by HIV give rise to many different gastrointestinal opportunistic infections, such as cytomegalovirus (CMV) infection and fungal esophagitis [1]. Helicobacter pylorus (H. pylori) is a gram negative, spiral, flagellate bacillus that naturally colonizes humans, living in their gastric mucus. And is the major etiologic factor of chronic gastritis and peptic ulcer in the general population. Gastrointestinal (GI) symptoms are frequent among patients infected with human immunodeficiency virus (HIV) and with acquired immunodeficiency syndrome (AIDS) [2] however, the role of H. pylori infection in the GI tract mucosa of HIV patients is not well defined [3]. Some studies suggested that interactions between the immune/inflammatory response, gastric physiology and host repair mechanisms play an important role in dictating the disease outcome in response to H. pylori infection, suggesting that the host’s immune competence might be an important issue in H. pylori infection [3]. Data in regard to the prevalence of H. pylori infection in HIV infected population are controversial. H. pylori related gastritis has been noted to occur less frequently (that is, in 5 to 59% of cases) in adult patients with the acquired immunodeficiency syndrome (AIDS) [4]. Some reports have shown that the rate of the infection in HIV-positive patients is remarkably low when compared with the general population [4,5]. Conversely, other studies have not found similar results.

Authors and Affiliations

Muringani BN, Mutsvanga T

Keywords

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EP ID EP566293
DOI 10.26717/BJSTR.2017.01.000165
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