Brain Tumor and Peritumoral Fibers Reconstruction and Visualization With 3D Slicer

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Brain Tumor and Peritumoral Fibers Reconstruction and Visualization With 3D Slicer

Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 1

Abstract

Objective: To explore a three dimensional (3D) visualization method for brain tumor and peritumoral fibers with 3D Slicer. Methods: 3D Slicer (version 4.8.1) was download from website (www.slicer.org) and installed. DTI Volume with a tumor was downloaded as a sample data from the sample module of 3D Slicer. The ranges which would be used to track the fibers around tumor were delineated on transverse and sagittal sections. Peritumoral nervous fibers were visualized with tractography seeding (a toolkit in 3D Slicer) based on manual label in fractional anisotropy (FA) image. Bundle shape was saved as vtk file and exported. The fibers were identified according the position in slices under an atlas. Results: The fibers around the tumor were composed as following: anterior part of corpus callosum was identified in the back of the tumor and interrupted by the tumor, arcuate fibers between superior frontal gyrus and inferior frontal gyrus was located in the top, lateral side and bottom of the tumor. Conclusion: Ranges labeled on transverse and sagittal sections could be used to visualize the fibers around tumor, vtk models of fibers could be used to identify the fibers.The function areas and fibers around tumor is very important for operation plan, the function area could be identified with functional MRI (fMRI) and diffusion MRI (dMRI) [1], the range of seed and selected region could affect the results of displaying the fibers around the tomur [2]. The occupation of tumor consist of a center and edema part, the center always shows a low intensity in T1 series, while the edema part has a little higher intensity than those in the center. It is necessary to identify the range of white matter to display the fibers around tumor. 3D Slicer supports a lot of modules such as segment, diffusion, and dMRI for segment, reconstruction and even fibers displaying functions [3-5]. In this paper, Diffusion module was employed to display the fibers, the authors drew a range with 10 mm width around the tumor. From Figure 3-Figure 5, the fibers could be displayed clearly and the special relationship between tumor and fibers is very clear. On the other hand, considering the direction of fibers, the label should be set both in transverse section (up-down going fibers) and sagittal section (left-right going fibers) which were approached in (Figures 3 & 4).

Authors and Affiliations

Dafeng Ji

Keywords

3D Reconstruction; Diffusion Tensor Imaging; Peritumor; 3D Slicer; Virtual Toolkit Journals on Biomedical Engineering Journals on Biomedical Science Journal on medical genetics Journals on Cancer medicine Journals on Medical Informatics Journals on Biomedical Imaging Journals on Biomedical Intervention Journals on Medical Microbiology Journals on Medical Casereports Journals on Medical drug and theraputics

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EP ID EP622662
DOI 10.26717/BJSTR.2019.19.003246
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