[Arginase Activity, Ornithine and Urea Levels in Breast Cyst Fluid]
Journal Title: Türk Biyokimya Dergisi/Turkish Journal of Biochemistry - Year 2006, Vol 31, Issue 3
Abstract
Gross cystic disease of breast is the commonest benign disease of breast effecting 1:20 women in the western world. There are two groups of breast cyst; lined either by metaplastic epithelium (Na/K3). There is clear parallelism between their electrolyte ratios and epithelial characters. Several large studies have shown that the risk of breast cancer in women with gross cystic disease to be 2 to 4,4 times higher and women with “apocrine” breast cyst may have a higher risk of developing breast cancer than women with breast cyst lined by flattened epithelium. Arginase, a cytoplasmic enzyme, catalyzes the hydrolysis of L-arjinine to urea and ornithine in the last step of the mammalian urea cycle. The most important function of arginase is the synthesis of urea. Arginase also plays an important role in the synthesis of polyamines through the ornithine. The aim of the present study was to compare the distributions of arginase, ornithine and urea concentrations in breast cyst fluid in the 2 sub-groups of breast cyst. The possible roles which arginase, ornithine and urea may have on breast cancer development were investigated. Arginase enzyme activities, ornithine and urea levels were significantly higher in the apocrine cyst group. There was no difference in protein levels between the two cyst groups. In conclusion the finding of high arginase activity and ornithine levels in high risk breast cyst group the breast cyst may lead to an increase in the production of polyamines which were shown to be tumor promoting agents, and thus may lead to development of breast cancer from the gross cystic breast disease.
Authors and Affiliations
Hakan Erbaş, Oya Erten, Aynur Dağlar, Mehmet İrfanoğlu
Keywords
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