Aromatase Inhibitors Combined with Growth Hormone: A Cost-effective Last Chance for Improving Boysâ Stature at the Near-End of Growth?
Journal Title: Journal of Clinical and Molecular Endocrinology - Year 2017, Vol 2, Issue 1
Abstract
Two studies have recently shown a clear benefit of using nonsteroidal aromatase inhibitors (AIs) in combination with growth hormone (rhGH) in pubertal boys of very short stature (between -2.5 and - 3 SDS) who are approaching the end of their growth [1,2]. AIs have been used in human therapeutics since the 1990s, mostly in adults [3], to block aromatase by binding to the heme iron of aromatase, a cytochrome p450 enzyme that catalyzes the formation of C18 estrogens (estrone and estradiol) from C19 androgens (androstenedione and testosterone) [4]. In males, circulating estradiol is derived from direct testicular secretion (20%) and from peripheral conversion of adrenal or testicular androgens [5,6].
Authors and Affiliations
Pierre Bougnères
Keywords
Related Articles
- EP ID EP305624
- DOI 10.21767/2572-5432.100036
- Views 33
- Downloads 0
Aromatase Inhibitors Combined with Growth Hormone: A Cost-effective Last Chance for Improving Boysâ Stature at the Near-End of Growth?
Two studies have recently shown a clear benefit of using nonsteroidal aromatase inhibitors (AIs) in combination with growth hormone (rhGH) in pubertal boys of very short stature (between -2.5 and - 3 SDS) who are approac...
Ketotifen and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus
Objective: Mast cells found to be an important contributor to inflammation, obesity, diabetes and atherosclerosis. We evaluate the ability of ketotifen to reduce cardiovascular risk in patient with type 2 diabetes millet...
Antidiabetics and Heart Failure - Large Trials but Little Mechanistic Insight
Glucose lowering efficacy was the basis for the approval of antihyperglycaemic drug in the past. However, increasing concerns emerged about potential cardiovascular side effects of these drugs following the metaanalysis...
Might Estrogen Promote Lung Cancer Progression?
In order to understand the differences between sexes in lung cancer presentation and due to the observation that young women have worse prognosis, we studied the participation of estrogens in lung carcinogenesis. We foun...
A Descriptive Study on Children with Congenital Adrenal Hyperplasia Attending Assiut University Children Hospital
Introduction: Congenital adrenal hyperplasia is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most...