Ketotifen and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus
Journal Title: Journal of Clinical and Molecular Endocrinology - Year 2017, Vol 2, Issue 1
Abstract
Objective: Mast cells found to be an important contributor to inflammation, obesity, diabetes and atherosclerosis. We evaluate the ability of ketotifen to reduce cardiovascular risk in patient with type 2 diabetes millets (T2DM). Method: In a randomized controlled study we recruited forty eight patients with T2DM from Internal Medicine Department at Tanta University Hospital, Egypt. They were classified in to three groups. Group 1: received glimepiride (GL) 3 mg/day alone; group 2: received GL 3 mg/day +ketotifen 1 mg once daily; group 3: received GL 3 mg/day +ketotifen 1 mg twice daily. Fasting blood samples were obtained before and 12 weeks after treatment for biochemical analysis of IL-6 and lipid profile with subsequent calculation of Castelli index 1 and atherogenic coefficient. Body mass index was also calculated for all patients. Data were analyzed by paired student's t-test and one way analysis of variance, p<0.05 was considered statistically significant. Results: The obtained data suggested that ketotifen in its twice daily dose significantly improves lipid profile and decreases IL-6 level, castelli index 1 and atherogenic coefficient. Conclusions: Mast cell stabilization with ketotifen can decrease the risk of diabetes associated cardiovascular complications
Authors and Affiliations
Sahar M El-Haggar, Wael F Farrag, Fedaa A Kotkata
Keywords
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- EP ID EP305601
- DOI 10.21767/2572-5432.100035
- Views 49
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