Might Estrogen Promote Lung Cancer Progression?
Journal Title: Journal of Clinical and Molecular Endocrinology - Year 2017, Vol 2, Issue 1
Abstract
In order to understand the differences between sexes in lung cancer presentation and due to the observation that young women have worse prognosis, we studied the participation of estrogens in lung carcinogenesis. We found that estradiol increases the expression of CXCR4 and promotes the activation of the CXCL12/CXCR4 axis, an important chemokine pathway involved in lung carcinogenesis and tumor progression.
Authors and Affiliations
Vianey Rodriguez Lara
Keywords
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- EP ID EP305648
- DOI 10.21767/2572-5432.100038
- Views 41
- Downloads 0
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