Assessing the Fidelity of the Malaria Vaccine Implementation in Malawi
Journal Title: Journal of Clinical & Cellular Immunology - Year 2023, Vol 14, Issue 5
Abstract
Globally, remarkable progress has been made in the fight against malaria over the last two decades, yet the rate of reduction of malaria case incidence and mortality seems stalled. Globally, malaria case incidence (i.e., cases per 1000 population at risk) reduced from 80 to 58 and only to 57 in 2019. Mosquirix (RTS, S/AS01), a four-dose malaria vaccine with an effectiveness of 39%, was piloted by the WHO in three countries including Malawi where it was integrated into the EPI as a regular schedule dose. Fidelity was assessed to evaluate the degree of adherence to the planned protocol for the roll out of the program. This is a qualitative study that used the implementation fidelity framework where 12 healthcare workers were interviewed, 47 parents attended 2 focused group discussions, and a non-participatory observation checklist determined the status of vaccine storage and administration, in 2 separate health centers serving as immunization clinics. Framework approach analysis was used in this study. 59 participants were interviewed in this study. 12 health workers that were interviewed, 2 (17%) were female and 10 (83%) were male whereas all 47 (100%) parents were female. The average age of HCWs was 38 years while for the parents it was 29 years. The study demonstrated fidelity to the malaria vaccine protocol but to a much lesser extent. It has to some extent been implemented with fidelity and there is demonstrable adherence to the vaccine protocol, nevertheless, numerous gaps still exist.
Authors and Affiliations
Parth K. Patel Linda Alinane Nyondo-Mipando Noel Kalanga
Keywords
Related Articles
- EP ID EP741787
- DOI 10.35248/2155-9899.23.14.697
- Views 14
- Downloads 0
Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CT...
Measurement of Post Challenging Immune Response (Serum?s Th1, Th2 Cytokines and Spleen?s CD Markers) with L.Major Amastigote in Balb/c Mice
Introduction: Leishmaniasis is a disease caused by the Leishmania major parasites and afflicted a large number of people every year. This disease is immunologically complex and in some cases, spontaneous improvement is a...
Secretory IgA and Course of COVID-19 in Patients Receiving a BacteriaBased Immunostimulant Agent in Addition to Background Therapy
Background: Mucosal immunity plays a major role not only in the prevention but probably also in the outcome of COVID-19. An enhanced production of secretory Immunoglobulin A (sIgA) might contribute to the activation of t...
A Phylogenomic Analysis of HIV Transmission Pattern among High Risk Groups of North-West India
Background: Molecular techniques can enhance the power of epidemiological investigations for tracing HIV transmission networks. This information could be useful for developing strategies for prevention of HIV transmissio...
Hotairm1 Controls S100A9 Protein Phosphorylation in Myeloid-Derived Suppressor Cells during Sepsis
During the acute phase of sepsis, the S100A9 proinflammatory protein resides in the cytosol in a phosphorylated form. In contrast, S100A9 relocalizes to the nucleus in an unphosphorylated form during the late/chronic sep...