Assessing the Fidelity of the Malaria Vaccine Implementation in Malawi
Journal Title: Journal of Clinical & Cellular Immunology - Year 2023, Vol 14, Issue 5
Abstract
Globally, remarkable progress has been made in the fight against malaria over the last two decades, yet the rate of reduction of malaria case incidence and mortality seems stalled. Globally, malaria case incidence (i.e., cases per 1000 population at risk) reduced from 80 to 58 and only to 57 in 2019. Mosquirix (RTS, S/AS01), a four-dose malaria vaccine with an effectiveness of 39%, was piloted by the WHO in three countries including Malawi where it was integrated into the EPI as a regular schedule dose. Fidelity was assessed to evaluate the degree of adherence to the planned protocol for the roll out of the program. This is a qualitative study that used the implementation fidelity framework where 12 healthcare workers were interviewed, 47 parents attended 2 focused group discussions, and a non-participatory observation checklist determined the status of vaccine storage and administration, in 2 separate health centers serving as immunization clinics. Framework approach analysis was used in this study. 59 participants were interviewed in this study. 12 health workers that were interviewed, 2 (17%) were female and 10 (83%) were male whereas all 47 (100%) parents were female. The average age of HCWs was 38 years while for the parents it was 29 years. The study demonstrated fidelity to the malaria vaccine protocol but to a much lesser extent. It has to some extent been implemented with fidelity and there is demonstrable adherence to the vaccine protocol, nevertheless, numerous gaps still exist.
Authors and Affiliations
Parth K. Patel Linda Alinane Nyondo-Mipando Noel Kalanga
Measurement of Post Challenging Immune Response (Serum?s Th1, Th2 Cytokines and Spleen?s CD Markers) with L.Major Amastigote in Balb/c Mice
Introduction: Leishmaniasis is a disease caused by the Leishmania major parasites and afflicted a large number of people every year. This disease is immunologically complex and in some cases, spontaneous improvement is a...
Assessing the Fidelity of the Malaria Vaccine Implementation in Malawi
Globally, remarkable progress has been made in the fight against malaria over the last two decades, yet the rate of reduction of malaria case incidence and mortality seems stalled. Globally, malaria case incidence (i.e.,...
Exercise-Mediated Immune Protection in Chronic Kidney Disease Decreases Infection and Severe Evolution of COVID-19
It is constantly sought to understand the different mechanisms of action of the immune system to establish potential efficient therapeutic targets for different clinical situations. Thus, the present study aims to expand...
The Pattern of CD4+ T Cell Recovery and Determinants of HIV Infected Individuals Receiving Highly Active Antiretroviral Treatment in Mekelle Hospital, Tigray Northern Ethiopia: A Retrospective Study
Background: With the development of antiretroviral treatment, the incidence of HIV-related illness and death has significantly decreased. Nevertheless, some individuals living with HIV who are taking Anti-Retroviral Ther...
Indoleamine 2,3-Dioxygenase (IDO); Silenced Dendritic Cell Vaccine with Ipilimumab in Treating Metastatic Melanoma Patients: A Case Report
Immunotherapy has revolutionized the treatment landscape for metastatic melanoma. This case report presents the clinical course of a patient with metastatic melanoma who received combination therapy with ipilimumab, a CT...