ASSESSING THE THERAPEUTIC ROLE OF JOSHANDA: PHYTOCHEMICAL, ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 2
Abstract
Objective: Joshanda, a polyherbal Unani formulation is extensively used as a common home remedy for the treatment of a cough and cold accompanied by pharyngeal inflammation and fever. This study aimed to analyze phytochemicals, antioxidant, anti-inflammatory, and antibacterial activity.Methods: The study investigated the presence of phyto-compounds in joshanda and antioxidant, antibacterial, anti-fungal, and anti-inflammatory activities by various in vitro standard methods using ascorbic acid, ampicillin, and aspirin respectively as standard drugs.Results: Joshanda aqueous extract revealed the presence of tannins, phenols, flavonoids glycosides, terpenoids, and alkaloids and absence of sterols, saponins, xanthoprotiens, and carboxylic acid. Joshanda showed the highest inhibition against B. subtilis (% MGI 99.000±0.577) and least inhibition against P. aeruginosa (%MGI of 84.102±0.491). Joshanda extract, ascorbic acid demonstrated highest % DPPH radical scavenging of 98.379±0.313%, 98.843±0.443% and a minimum of 36.210±1.174%, 83.192±0.422%. Results showed H2O2 scavenging activity of 0.047±0.001 μg/ml per minute degradation of H2O2. FRAP value was observed in joshanda and ascorbic acid with a maximum of 0.945±0.024, 0.687±0.047 mmol and minimum of 0.171±0.036, 0.059±0.005 mmol respectively. Joshanda extract showed the highest albumin denaturation inhibition of 14.069±0.350% and the lowest of 1.880±0.194% at extract volume of 1000 µl and 100 µl respectively. The extract demonstrated the highest proteinase inhibition of 24.003±0.291 % and the lowest of 4.959±0.254% comparable to aspirin. Joshanda had no potent anticandidal activity up to 1 mg/ml.Conclusion: Results clearly suggested that joshanda is a potent phytodrug and can also be used as a strong reactive oxygen species scavenger, might be used as anti-arthritic and strong natural antibiotic agent for effective treatment of various oxidative stressed disorders.
Authors and Affiliations
Tooba Naz Shamsi, Romana Parveen, Archoo Sajida, Afaque Ahmad, Sadaf Fatima
Keywords
Related Articles
- EP ID EP575377
- DOI 10.22159/ijpps.2018v10i2.22450
- Views 86
- Downloads 0
TOXICITY EVALUATION OF HYDRO-ALCOHOLIC EXTRACT OF PORTULACA OLERACEA (WHOLE PLANT) IN SWISS ALBINO MICE
Objective: To evaluate the toxicity (acute and sub-acute) of hydro-alcoholic extract of Portulaca oleracea (whole plant) in Swiss albino mice.Methods: Acute oral toxicity study was carried out as per OECD 423 guidelines....
SYNTHESIS AND FORMULATION OF IBUPROFEN PRO-DRUGS FOR ENHANCED TRANSDERMAL ABSORPTION
Objectives: The aim is to synthesize ibuprofen prodrugs that have more suitable physicochemical properties and formulate them into a liquid formulation for topical administration. The transdermal delivery (TDD) is one of...
ANTIDEPRESSANT ACTIVITY OF AQUEOUS EXTRACTS OF FRUITS OF TERMINALIA CHEBULA AND PHYLLANTHUS EMBLICA IN BEHAVIOURAL MODELS OF DEPRESSION: INVOLVEMENT OF MONOAMINERGIC SYSTEM
Objectives: Terminalia chebula (TCh) and Phyllanthus emblica (PE) posses wide range of central nervous system activity. This study was conducted to investigate the antidepressant activity and mechanism action of aqueous...
TELMISARTAN ALLEVIATES NITROSATIVE STRESS IN TURN DOPAMINERGIC DEGENERATION IN MICE MPTP MODEL OF PARKINSONISM–BIOCHEMICAL AND HISTOPATHOLOGICAL EVIDENCES
Objective: Telmisartan (TEL), an angiotensin type 1 receptor blocker, exerts neuroprotection in MPTP induced Parkinson’s disease. The present study was aimed to investigate its effects on oxidative stress markers–ind...
PREVALENCE AND RISK FACTORS OF GASTROESOPHAGEAL REFLUX DISEASE (GERD) IN ADULT KASHMIRI POPULATION
Objective: The study was conducted with the objective of studying the prevalence of gastroesophageal reflux disease (GERD) and to study various factors associated with it in adult Kashmiri population.Methods: It was a co...