Assessment of Alanine Aminotransferase (ALT) Level as a Risk Factor Among Chronic Hepatitis B Infection Patients: A Retrospective Analysis Over a Period of 20 Years
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Introduction: Liver conditions such as liver cirrhosis and HCC are caused by CHB progression. ALT; is a marker of hepatocyte inflammation. Repeated periodic testing is recommended for liver evaluation. High results of ALT suggest a significant hepatic inflammation, and several studies show that it could increase the risk of disease progression. In this study, we want to find out if the time period of different stages of CHB infection progression is affected by the level of ALT, by tracing the patients’ medical and treatment history for the past 20 years in one of the tertiary governmental hospital in KSA. Materials and Methods: The present retrospective cohort study consisted analysis of 384 cases of patients who were diagnosed and treated for CHB infection at King Fahad General Hospital (600 bed capacity), Jeddah City. The data was extracted from the medical records dated January1996 to December 2016. Data was evaluated using the Kaplan–Meier method and the log-rank test. The univariate and multivariate Cox regression model were applied to identify independent predictors of failure with the likelihood ratio test as the measure of significance.. P values less than 0.05 were considered as statically significant. Results: The mean change from enrollment of ALT is (-41.57) with a SD of (131.08) and a median of (-15.1). The P value based on Wilcoxson Signed Rank Test is <0.0001, which means the ALT reduction from enrollment is statistically significant. High ALT level were not significantly prompting the development of the Compensated Cirrhosis (CC) and decompensated cirrhosis (DC). Conclusion: In contrast to many studies in the literature, high levels of ALT did not correlate to the long-term outcome of HBV infection in this research. Different population characteristics might be the major reason behind those differences in results.
Authors and Affiliations
Manahil Aldar, Faisal Batwa, Naeema Akbar
Keywords
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- EP ID EP548742
- DOI 10.21276/ijmrp.2017.3.6.026
- Views 93
- Downloads 0
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