Assessment of Analgesic and Neuropharmacological Activity of Different Extracts of Euphorbia hirta (Linn.) Leaf
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 2
Abstract
Aims: The present study was carried out to investigate the possible analgesic and neuropharmacological activities of the aqueous, ethanol and ethyl acetate extracts of Euphorbia hirta (Linn.) leaves. Methods: The analgesic and neuropharmacological potential was studied at the dose of 400 mg/kg of body weight in mice. Analgesic potential of the extracts was evaluated using mice writhing method and formalin induced pain tests. In addition, neuropharmacological property of extracts was carried out by hole cross, open field and elevated plus maze tests. Results: In writhing test, the aqueous extract significantly (89.51%) inhibited the peripheral nociception while in formalin test the ethyl acetate extract significantly (p>0.001) inhibited the licking time in both phases. The ethanolic extract exhibited convincing reduction of exploratory behavior in hole cross and open field tests. Furthermore, an increase in the frequency and duration in the open arm of EPM displayed by all three extracts indicates the evidence of their anxiolytic activity. Conclusion: These results may rationalize the scientific basis for use of this plant in traditional medicine for treatment of analgesia and anxiety related disorders.
Authors and Affiliations
Md. Razibul Habib, Mohammad Mustakim Billah, Kashfia Nawrin, Md. Rakibul Hasan, Md. Ibrahim Khalil, Md. Mominur Rahman
Keywords
Related Articles
- EP ID EP342094
- DOI 10.9734/BJPR/2016/21838
- Views 94
- Downloads 0
Tetrapleura tetraptera Taub- Ethnopharmacology, Chemistry, Medicinal and Nutritional Values- A Review
Ethnopharmacological Relevance: Tetrapleura tetraptera Taub (Fabaceae-Mimosoideae) is a well-known tree growing widely in forest zones all over West Africa. It is used in wound-healing, diabetes mellitus, asthma, hyperte...
In-vitro Fundamental Assessment of Disintegration and Dissolution Profile of Enteric Coated Rabeprazole Tablet Commercially Accessible in Bangladesh
Objective: An assortment of commercially accessible enteric coated rabeprazole tablets were evaluated comparatively in vitro disintegration and dissolution profile in association with its’ drug content. Methods: In-vitro...
Evaluation of Thrombolytic Effect of Seven Different Bangladeshi Plants
Aim: From time past till date, proper documentation of the use of medicinal plants are helpful in drug development and research. The objective of this study is to evaluate several plant extracts of Bangladesh for their t...
Phyto Medicinal Compounds from Urginea indica Kunth: A Synthetic Drugs Potential Alternative
Urginea indica belongs to Lilliaceae family the analysis of bioactive compounds through GCMS analysis revealed the presence of various phytosterols, organic acids, esters, phenoles and ketones have identified. The 36 com...
Study of Preventive Effectiveness of Nigella sativa L. against Rat kidney Stones, Generated by Ethylene Glycol
Aims: The objective of this research is to study the preventive effectiveness of Nigella sativa L. against rat kidney stones, generated by Ethylene Glycol. Methodology: In this study, 40 Wistar rats were categorized r...