Assessment of antibacterial, anti-inflammatory and antioxidant effects of Nyctanthes arbor tristis - an in-vitro study.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Background and objectives: Periodontitis is a chronic inflammatory disease of multi-factorial etiology with microbial plaque being the primary cause. Various treatment modalities have been utilized in the management of periodontal diseases. Phytochemicals in the periodontal therapy has been evolved in the recent years with diverse benefits. Nyctanthes arbor-tristis a plant with many medicinal properties. The aim of this study was to assess the antibacterial, anti-inflammatory and antioxidant activity of Nyctanthes arbor-tristis leaf extract (NAL) under laboratory condition. Methods: In the present study, Nyctanthes arbor-tristis leaf extract was assessed for its antibacterial effects against Streptococcus mutans, Streptococcus sanguis, Staphylococcus aureus and Porphyromonas gingivalis using agar disc diffusion method and minimum inhibition concentration (MIC). The anti-inflammatory effect was assessed by lipoxygenase inhibition assay and hyaluronidase inhibition assay. The antioxidant effects were assessed by ABTS and DPPH antioxidant assays. The statistical analysis was done by One-way ANOVA test, Independent Student t-test and Mann Whitney U Test. Results: On comparison between the groups, the test results revealed that chlorhexidine showed higher mean zone of inhibition against the tested organisms. The test results of DPPH assay and ABTS assay revealed that the quercetin had higher radical scavenging property as compared to Nyctanthes arbor-tristis leaf extract. The test results of lipoxygenase inhibition assay and hyaluronidase inhibition assay revealed that the control groups showed higher percentage of lipoxygenase inhibition activity and hyaluronidase inhibition activity. The difference in results obtained were not statistically significant. Conclusion: Nyctanthes arbor-tristis leaf extract showed antibacterial effect on the tested organisms and insignificant anti-inflammatory and antioxidant property. Hence; further studies with large sample size and under in-vivo and vitro conditions have to be conducted.
Authors and Affiliations
Dr. Shahna N.
Keywords
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