ASSESSMENT OF ANTIEMETIC POTENTIAL OF CRUDE EXTRACT OF VIGNA TRILOBATA (LINN.) AGAINST DIFFERENT EMETOGENIC STIMULI; AN IN VIVO STUDY
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2015, Vol 5, Issue
Abstract
Vigna trilobata (Linn.) is used in traditional system for the treatment of many ailments in Asia. The present study is an attempt to evaluate the antiemetic activity of V. trilobata (50 and 100 mg/kg of body weight) by using the chick emesis model. Different emetogenic stimuli such as, copper sulphate (CuSO4, oral), fresh juice of Brasica compestris (oral) and cisplatin (I.V) were used to induce emesis in 10-15 days old chicks of either sex. Antiemetic activity was assessed by calculating the mean decrease in number of retching in contrast with those of control. V. trilobata showed a significant antiemetic activity (p<0.05), when compared with standard antiemetic drugs, metoclopramide, domperidone and chlorpromazine. Further studies are under process, regarding the isolation and purification of active constituents responsible for the antiemetic activity of V. trilobata.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP538334
- DOI -
- Views 105
- Downloads 0
SPECTROPHOTOMETRIC DETERMINATION OF NARATRIPTAN HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple efficient, precise and accurate spectroscopic method has been developed and validated for quantitative estimation of Naratriptan Hydrochloride in bulk and pharmaceutical dosage form. Naratriptan is dissolved in...
ROLE OF HYDROPHILIC POLYMERS ON THE STABILITY OF FORMULATIONS OF TENOXICAM – SBE7-β-CD INCLUSION COMPLEX
The present study was carried out to evaluate the usefulness of sulfobutyl ether β-Cyclodextrin (SBE7-β-CD) in increasing the dissolution rate of tenoxicam. The approach employed to prepare the inclusion complexes of the...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND N-ACETYLCYSTINE IN ITS BULK AND EFFERVESCENT TABLET DOSAGE FORM
Abstract The present study describes a simple, accurate, precise and cost effective Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method for simultaneous estimation of Paracetamol and N-Acetylcysteine in...
SOLUBILITY ENHANCEMENT OF NIFEDIPINE BY USING LIQUISOLID COMPACT TECHNIQUE
Abstract This study evaluated the feasibility of liquisolid compact as an innovative drug delivery system to improve the solubility of the poorly soluble drug Nifedipine. There are several techniques to enhance the disso...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND DACLATASVIR DRUG PRODUCT BY RP-HPLC METHOD
Abstract Analytical method was developed for the estimation of Sofosbuvir and Daclatasvir drug substance by liquid chromatography. The chromatographic separation was achieved on C18 column (XTerra RP18 150*4.6, 5um) at a...