Assessment of antioxidant enzyme status and lipid peroxidation in different KL grade knee osteoarthritis patients
Journal Title: Santosh University Journal of Health Sciences - Year 2018, Vol 4, Issue 2
Abstract
Introduction Although limited information is available about the pathophysiology of knee osteoarthritis OA disease in relation with oxidative stress there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OAAim To estimate the levels of antioxidant enzymes and malondialdehyde MDA in the knee OA patients of different KL grade and to determine the variation in their levels with severity of diseaseMaterials and Methods Antioxidant enzyme status superoxide dismutase and ceruloplasmin and malondialdehyde levels were measured in 150 knee OA patients 3565 years by using standard methods On the basis of KL grading scale Knee OA patients were categorized into three groups n50 in each group and statistically compared it with that of 50 healthy controls by using students ttestResults Erythrocyte superoxide dismutase activity was significantly low in Group II P Conclusion Study findings indicate that alteration in antioxidant enzyme status and increased production of MDA are excellent marker of oxidative stress in different grades of knee OA patients Thus the diet rich in antioxidant or antioxidant supplementation could be beneficial in delaying the progressive destruction of articular cartilage process and serve as a preventive strategy in field of knee OA managementKeywords Superoxide dismutase ceruloplasmin free radicals Malondialdehyde Oxidative stress
Authors and Affiliations
Jyoti Batra, Rahul Saxena, Gladys Rai, Saurabh Srivastava, Rajni Ranjan
Keywords
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- EP ID EP488986
- DOI 10.18231/2455-1732.2018.0022
- Views 102
- Downloads 0
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