Assessment of antioxidant enzyme status and lipid peroxidation in different KL grade knee osteoarthritis patients
Journal Title: Santosh University Journal of Health Sciences - Year 2018, Vol 4, Issue 2
Abstract
Introduction Although limited information is available about the pathophysiology of knee osteoarthritis OA disease in relation with oxidative stress there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OAAim To estimate the levels of antioxidant enzymes and malondialdehyde MDA in the knee OA patients of different KL grade and to determine the variation in their levels with severity of diseaseMaterials and Methods Antioxidant enzyme status superoxide dismutase and ceruloplasmin and malondialdehyde levels were measured in 150 knee OA patients 3565 years by using standard methods On the basis of KL grading scale Knee OA patients were categorized into three groups n50 in each group and statistically compared it with that of 50 healthy controls by using students ttestResults Erythrocyte superoxide dismutase activity was significantly low in Group II P Conclusion Study findings indicate that alteration in antioxidant enzyme status and increased production of MDA are excellent marker of oxidative stress in different grades of knee OA patients Thus the diet rich in antioxidant or antioxidant supplementation could be beneficial in delaying the progressive destruction of articular cartilage process and serve as a preventive strategy in field of knee OA managementKeywords Superoxide dismutase ceruloplasmin free radicals Malondialdehyde Oxidative stress
Authors and Affiliations
Jyoti Batra, Rahul Saxena, Gladys Rai, Saurabh Srivastava, Rajni Ranjan
Keywords
Related Articles
- EP ID EP488986
- DOI 10.18231/2455-1732.2018.0022
- Views 111
- Downloads 0
Clinical profile of women with post coital bleeding
Background: Post-coital bleeding increases the risk of serious pathology in women. Method: This prospective study was carried out in 75 women attending the gynaecology OPD with complaints of post coital bleeding and 75 w...
Nano drug delivery system: An insight with review
Nanotechnology is the science of material featuring between 109 and 107 of a meter Pharmaceutical nanotechnology is the latest advancement in pharmacology known for presenting multiple newer tools opportunities and scope...
Frontal meningioma presenting as depressive episode: case report and a brief review of literature
Brain tumours have been notorious for impersonating as psychiatric disorders. In some cases, patients may only have psychiatric symptoms, such as mood changes (depression or mania), psychotic symptoms, panic attacks, cha...
Mental foramen: An Indicator for Gender Determination - A Radiographic Study
Background: The identification of sex from human remains is of fundamental importance in forensic science. Among the skeletal components pelvis and skull, with mandible being the practical element are used for gender det...
Tooth Bleaching- Home Bleaching Technique
Bleaching is a procedure which involves lightening of the color of a tooth through the application of a chemical agent to oxidize the organic pigmentation in the tooth. Tooth discoloration varies in etiology, appearance...