Assessment of Autonomic Dysfunctions in Altered Thyroid Status by Time Domain Parameters of HRV
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Thyroid hormone has important effects on the cardiovascular system. Many signs and symptoms recognized in patients with of thyroid disorders (hyperthyroidism and hypothyroidism) are due to the increased or reduced action of thyroid hormone on the cardiovascular system. The aim of the study was to assess the cardiac autonomic functions by time domain parameters of heart rate variability in patients with hypothyroidism, hyperthyroidism and to compare it with healthy controls. Autonomic functions were evaluated by measurement and analysis of time domain parameters of HRV by ECG method and scored in 50 hypothyroid, 50 hyperthyroid patients, 20-60 years and compared with 25 controls. The present study was conducted in the Dept. of Physiology, SMS Medical College, Jaipur with the collaboration of Dept. of Endocrinology of the Institute. Informed written consent was obtained from all the subjects included in the study. Biochemical estimation of TSH, fT3, fT4 was done. Results were presented as Mean ± SD. For statistical analysis, One Way ANOVA (Post Hoc Tukey) test was used. In hyperthyroids and hypothyroids the mean values of SDNN, RMSSD, pNN50 were found significantly lower (p<0.001) than controls. Thus our finding showed autonomic dysfunction with decrease parasympathetic activity in both hypothyroids and hyperthyroids than controls. Keywords: Heart rate variability(HRV), Hypothyroidism, Hyperthyroidism, SDNN, RMSSD, pNN50.
Authors and Affiliations
Manisha Mavai, R. C. Gupta, Keerti Mathur, Kamla Chaudhary
Keywords
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