Assessment of Carcino-embryonic Antigen and Carbohydrate Antigen 19-9 Serum Levels in Pre-operative Sudanese Colorectal Carcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Colorectal cancer (CRC) is one of the most common cancer related causes of morbidity and mortality in developed countries. The use of tumor markers is a good way to improve the prognosis and treatment. This study aimed to evaluate the prognostic value of the two markers in fifty patients with CRC (as a test group) compared to twenty five apparently healthy persons (as a control group). The test group included in this study was from National Cancer Institute (NCI-Sudan), the test and the control groups were matched in term of age. Tumor markers Carcinoembryonic antigen (CEA) and CA 19-9 were determined by Electrochemiluminescence Immunoassay (ECLIA) using commercial kits from Roche Company (Germany) and Cobas e 411Immunoassay Analyzer. Patients with colorectal cancer showed highly significant increases in CEA and CA19-9 compared to the control group (p < 0.01), and more advanced tumor stage showed a highly significant increase in the levels of CEA and CA 19-9, and also a significant increase in patients above 60 years of age (p < 0.05) but no relationship between the levels of CEA and CA 19-9 levels with sex. Our results suggest that; serum concentrations of CEA and CA 19-9 can be helpful in the diagnosis and staging of colorectal carcinoma (CRC). On the other hand we suggest these marker levels could be of great screening value to detect CRC in its early stage.
Authors and Affiliations
Waleed A. Salim, Omer Fadl Idris, A. H. Khatab, Abubaker M. Hamad, Abdelgadir Elmugadam
Keywords
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- EP ID EP557254
- DOI 10.9790/0853-1803126164.
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