Assessment of Cardioprotective Effects of Aqueous and Ethanolic Extracts of Stem Barks from Trichilia emetica against Cardiotoxicity Induced by Doxorubicin in Wistar Rats
Journal Title: Cardiology and Angiology: An International Journal - Year 2016, Vol 5, Issue 4
Abstract
Aims: This study was to evaluate cardioprotective effects of extracts of stem barks from Trichilia emetica against cardiotoxicity induced by doxorubicin. Methodology: This experiment was performed as follows: Group I receives some distilled water; group II receives doxorubicin only. Group III was administered 25 mg/kg b. w. of resveratrol only; Group IV received 25 mg/kg b. w. of resveratrol + doxorubicin. The groups V, VI, VII and VIII received respectively, 100 mg/kg b. w. of ethanolic extract + doxorubicin, 100 mg/kg b. w. of aqueous extract + doxorubicin, 200 mg/kg b. w. of ethanol extract + doxorubicin and 200 mg/kg b. w. of aqueous extract + doxorubicin. The other groups IX, X, XI and XII also received 100 mg/kg b. w. of aqueous extract, 200 mg/kg b. w. of aqueous extract, 100 mg/kg b. w. of ethanol extract and 200 mg/kg b. w. of ethanolic extract respectively. Distilled water, resveratrol and extracts were administered orally for 14 consecutive days. Doxorubicin was administered only on the 13th day by intraperitoneal route. 48 hours after administration of doxorubicin, blood samples were collected for biochemical analyzes: CK-MB, CPK, LDH, transaminases and lipid profile. Results: Doxorubicin treated rats showed a significant (P˂0.05) increased in activity of creatinine kinase-MB (CK-MB), creatinine phosphokinase (CPK), lactate deshydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglycerides, total-cholesterol and LDL-cholesterol compared to the control group. The results showed a significant decrease in HDL-cholesterol in comparison with the control group. However, pretreatment of rats with the extracts induced a significant decrease of the same enzymes, Total- Cholesterol, LDL- Cholesterol, triglycerides but also by a significant increase in HDL-cholesterol relative to the group of doxorubicin. Conclusion: The results suggest that extracts of stem barks from Trichilia emetica possess cardioprotective effect.
Authors and Affiliations
Djoupo Agnon Prisca, Yapi Houphouët Félix, Yapo Adou Françis
Keywords
Related Articles
- EP ID EP327666
- DOI 10.9734/CA/2016/27626
- Views 67
- Downloads 0
Awareness and Attitudes of University of Ibadan Freshmen towards Learning and Performing Cardiopulmonary Resuscitation
Objectives: To assess the level of awareness of cardiopulmonary resuscitation (CPR), and the attitude of the University of Ibadan (UI) freshmen towards learning CPR, and performing CPR on cardiac arrest victims. Methods...
Acute Rheumatic Fever among Primary School Students in Harari Region, Eastern Ethiopia
Background: In many developed countries, acute rheumatic fever is eradicated through strong health promotion and prevention efforts; yet, it continues to cause serious health problems in many developing countries includi...
Hypertension and Uterine Artery Waveform
Background: Pregnancy Induced Hypertension is a multisystem heterogeneous disorder occurring in 4-7% of all pregnancies. Fetal villi in the intervillous space at fetomaternal interphase show ischemic, oxidative and immun...
Assessment of Cardioprotective Effects of Aqueous and Ethanolic Extracts of Stem Barks from Trichilia emetica against Cardiotoxicity Induced by Doxorubicin in Wistar Rats
Aims: This study was to evaluate cardioprotective effects of extracts of stem barks from Trichilia emetica against cardiotoxicity induced by doxorubicin. Methodology: This experiment was performed as follows: Group I rec...
Prevalence and Effects of Various Risk Factors Influencing the Blood Pressure Values
Aim: Hypertension is major cardiovascular risk factor contributing to all cause mortality. The present study was aimed to determine the impact of socio-demographic variables and risk factors on the blood pressures (BP) o...