Left Ventricular Hypertrophy and Incidence of Acute Coronary Heart Disease and Mortality in the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS)
Journal Title: Cardiology and Angiology: An International Journal - Year 2015, Vol 3, Issue 1
Abstract
Objective: To examine the relationship between left ventricular hypertrophy (LVH) and the incidence of acute coronary heart disease (CHD) and mortality in the modern era. Methods: We studied 16, 390 black and white participants free of clinical CHD from a US national sample. The independent prognostic value of ECG-LVH was determined by Cornell voltage (CV) for risk of incident acute CHD and total mortality overall and by race and sex. Results: 410 incident acute CHD events and 993 deaths occurred over a median follow-up of 4.8 years. CV LVH was associated with outcomes: more common in blacks (4.1%) than whites (1.2%) and in women (3.9%) than men (1.3%). However, men with CV LVH (HR 2.12 [95% CI 1.02-4.42) had greater risk for incident acute CHD than women (HR 1.29 [95% CI 0.79-2.11]) after adjusting for demographic, behavioral and clinical variables. By contrast, CV LVH conferred similar hazards for incident acute CHD among blacks (HR 1.63 [1.00-2.68; p=0.050]) and whites (HR 1.58 [95% CI 0.76-3.28; p=0.22]). Mortality associated with CV LVH was elevated overall (HR 1.31 [95% CI 1.00-1.71]) and for blacks (HR 1.36 [95% CI 1.00-1.86]) but not whites (HR 1.16 [95% CI 0.70-1.94]), with similar risk for women (HR 1.24 [95% CI 0.92-1.67] and for men (HR 1.30 [95% CI 0.72-2.35]). Conclusion: In this contemporary cohort, CV LVH was significantly prognostic for incident acute CHD for men but not women and there was no evidence of race differences. However, CV LVH was significantly prognostic for total mortality for blacks but not whites without evidence of sex differences.
Authors and Affiliations
Ronald J. Prineas, Anh Le, Stephen P. Glasser, Vera Bittner, William M. McClellan, Xin Wang, Yulia Khodneva, Monika M. Safford
Keywords
Related Articles
- EP ID EP344102
- DOI 10.9734/CA/2015/13917
- Views 55
- Downloads 0
Learning Bayesian Networks Using Heart Failure Data
Background: Several factors may affect heart failure status of patients. It is important to investigate whether or not the effects are direct. The purpose of this study was learning Bayesian networks that encode the join...
Assessment of a Cardiac Rehabilitation Program Based on the Borg RPE Scale by Six-minute Walk Test: A Pilot Study
Aims: The ability of cardiac rehabilitation to reduce mortality in those with cardiovascular disease is well established. Despite its widespread use in the clinical setting, the Borg Rating of Perceived Exertion (RPE) sc...
Nstemi “But” Stemi-De Winters Sign
Anterior ST elevation myocardial infarction can present with a specific electrocardiographic (ECG) pattern without ST segment elevations, known as De Winter sign. Recognizing this ECG pattern is important since it is con...
Chasing Complications of Balloon Mitral Valvotomy
Percutaneous balloon mitral valvotomy (BMV) done for mitral stenosis (MS) though largely improved nowadays can be followed by multiple and rare procedure related complications. We present an interesting case of a 45 year...
Haemodynamic Responses to Tobacco Smoke Inhalation in Male Adolescents in Lusaka, Zambia
Background: Tobacco smoke is said to cause changes in the levels of catecholamines in the blood, this leads to an increase in blood pressure and heart rate. This is due to nicotine which has also been noted to cause a de...