Assessment of Cardiovascular Functions in Survivors of Breast Cancer Patients Treated with Chemo-Radiation
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Keeping in view the increasing incidence and better survival with treatment modalities of breast cancer and the associated toxicities, this study was intended to study the long term impact of these treatment modalities on cardiovascular status in survivors of carcinoma breast patients in Kashmir valley of Indian subcontinent. Material and methods: A prospective study in which breast cancer patients treated by combined modality treatment protocol with curative intent were taken for study. Patients with any co-morbid medical conditions like chronic lung disease, hypertension, asthma or drug intake for the same or any were not included in the study. Patients included in the study group had histopathological documentation of Carcinoma Breast, female sex, age greater than 18 years and geographical location of Kashmir Valley. Patients were subjected to echocardiography (M-Mode/2D/Colour Doppler) using Toshiba Power vision System. Standard imaging protocol was used. Left valvular function, valvular regurgitation, pulmonary hypertention and pericardial effusion /constriction was assessed. Results: The personnel habits and characteristics between the two groups were comparable. Serial echocardiography findings in study group were more or less similar over a period of two years. Only one new patient developed pericardial effusion. Incidence of diastolic dysfunction progressively increased from 9/50 cases to 12/50 cases. One new patient had developed mitral valve involvement and one new patient tricuspid involvement (p >0.05). Conclusion: Apart from the clear benefits of adjuvant chemo radiation, we should be aware of the potentially increased risk of cardiovascular and pulmonary sequelae following specific radiotherapy regimens in long-term breast cancer survivors. It is important to realize that our role as oncologists is not only to treat the tumour but also to improve the quality of life of our patients by preventing and treating the long term toxicities induced by chemo radiation. Majority of the patients were having echocardiography documented asymptomatic cardiac abnormalities. At a mean follow up interval of 5.8 years in the beginning of study 12/50 (24%) were having cardiac sequelae. Over a time period of 2 years three new patients developed asymptomatic cardiac problems. The follow up time was less, need more follow up time and larger studies.
Authors and Affiliations
Mansoor ul haq Lone, Refut Arah Banoo, Mohammad Ashraf, Nazir Ahmad Khan, Khurshid Aslam, Zahoor Ahmad Wafai
Keywords
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