Glycemic Impact of Individual Oral hypoglycemic Drugs in Type 2 Diabetes Mellitus- An Observational Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 11
Abstract
Introduction: The Incidence and prevalence of type 2 diabetes mellitus around the world is dramatically increasing over the past decades. Study aimed to assess the effectiveness of various Oral Hypoglycemic drugs on glycemic levels in established Type 2 Diabetes Mellitus patients. Material and Methods: In the present study 300 diabetic patients were selected and randomized into three groups. Group A comprised 100 patients whose baseline glycemic parameters were recorded and patients received Vildagliptin 50 mg twice a day, whereas Group B comprised of 100 patients and these patients received metformin 0.5gm–2gm/ day and Group C comprised of 100 patients and these patients received Voglibose 0.2mg thrice a day for 24 weeks. Patients were monitored closely for ensuring the compliance to diet, drug and exercise. Result: In the present study patients were randomly divided into three groups, Group A on Vildagliptin 50 mg, Group B on metformin 500mg – 2000mg. Group C on Voglibose 0.2mg. These entire three groups baseline FBS, PLBS, HBa1C was estimated prior to the study. It was observed that the mean baseline HBA1c in the Group A patients was 7.83 % and in Group B was 7.92%, Group C was 7.94% whereas the mean HbA1c after 24 weeks of therapy was 7.42%, 7.78% and 7.81% respectively in the Group A, B, and C. There was a significant decrease in HBA1c in all these three groups and it was statically significant. Conclusion: In summary, all three Oral hypoglycemic agent vildagliptin or metformin or voglibose monotherapy helped in improving glycemic control in patients with type 2 diabetes mellitus.
Authors and Affiliations
Anjum Sultana Khatoon, Md. Mansoor Ali Khan Lodhi
Keywords
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