Study of Assessment of Plasma Homocysteine Level in Microvascular Complications of Type 2 Diabetes Mellitus
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: Diabetes mellitus along with its complications bears a pertinent threat to human well being. The macrovascular and microvascular complications of diabetes contributes significantly to the mortality and morbidity caused by this disease. Recently, the elevated levels of plasma homocysteine have been linked with the development of these complications. This study was aimed to assess the plasma homocysteine levels in the microvascular complications of diabetes. Material and Methods: This case control study evaluates the frequency of hyperhomocysteinemia in patients with diabetes mellitus. A total of 80 randomly selected Type-2 Diabetes Mellitus patients were included in this study after taking informed consent. These patients were grouped into two categories, Group A consisted of those patients who had Diabetes with Microvascular complication, Group B included diabetic patients without any complications and Group C (controls) included 20 healthy subjects. Detailed clinical history was taken and appropriate blood tests were performed. Results: The mean age group of Group A, Group B and healthy controls were 52.94±10.46, 51.13±7.10, and 49.15±11.75 respectively. The mean serum homocysteine levels in patients with all three microvascular complications were significantly higher than other patients. The mean homocysteine level was 18.596±6.03, 13.74±3.46 and 11.085± 4.7 in Group A, Group B and healthy controls respectively. This difference was found to be statistically significant when analyzed by ANOVA test, F value being 17.28 and Fcritical being 3.2 and p=0.00. Conclusion: Plasma homocysteine level in diabetic patients with microvascular complications is an important biomarker and hence should be routinely evaluated in these patients.
Authors and Affiliations
Praneet Ansal Mundu, Bindey Kumar, Jeewan Kumar Mitra, Manish Kumar, Rashmi Sinha
Keywords
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