ASSESSMENT OF CLONIDINE AND DEXEMEDETOMIDINE AS ADJUVANT TO IV REGIONAL ANESTHESIA: A COMPARATIVE STUDY
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 1
Abstract
Background: Nowadays most commonly technique used for short operative procedures on extremities is Intravenous regional anesthesia (IVRA).Numerous methods have been used for improvising of peri-operative analgesia but neither of them proved to be ideal. The aim of present study is the assessment of clonidine and dexmedetomidine as adjuvant to IV regional anesthesia by comparative method. Materials and methods: 120 patients were selected for the present study who were planned to undergo elective upper limb orthopedic surgeries. The age of patients ranged between 18-60 years. Patients were randomly divided into two groups of 60 each: Group 1 and Group 2. Study drug used in Group 1 was 0.5% lignocaine (40 ml) + clonidine 1µg/kg and in Group 2 was 0.5% lignocaine (40 ml) + dexmedetomidine 1µg/kg. 40 ml of lignocaine 0.5% was prepared by adding 30 ml normal saline to 10 ml of 2% lignocaine. Results: There were significant differences in mean onset and recovery of sensory block between both the groups. In group 1, the sensory block onset time was 6.56 + 1.24 minutes and sensory block recovery time was 5.4 + 1.27 minutes. In group 2, the sensory block onset time was 4.69 + 1.43 minutes and sensory block recovery time was 7.86 + 1.79 minutes. Similarly, significant differences were observed in mean onset and recovery of motor block between both the groups. In group 1, the motor block onset time was 12.46 + 1.89 minutes and motor block recovery time was 7.4 + 0.75 minutes. In group 2, the motor block onset time was 9.2 + 1.98 minutes and motor block recovery time was 10.2 + 1.73 minutes (P<0.001). Conclusion: Addition of dexmedetomidine to local anesthetic for IVRA, significantly accelerated onset and prolonged the recovery of sensory as well as motor block in contrast to clonidine.
Authors and Affiliations
Madan Lal Kapoor, Pallavi Kapoor
Keywords
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