ASSESSMENT OF COLORECTAL CARCINOMA WITH EMPHASIS ON OUTCOME OF YOUNG AGED PATIENTS- A STUDY OF 62 CASES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 30
Abstract
BACKGROUND Colorectal Carcinoma (CRC) is an upcoming aggressive malignancy, especially among young adult population in recent years. This study emphasises on assessing disease burden and its outcome in young age colorectal carcinoma patients. The aim of this study is to assess aggressiveness of disease among all CRC patients and to evaluate, post treatment, patient’s outcome in all age groups with special emphasis on young age (<40 years). MATERIALS AND METHODS A study of patients with features of CRC was conducted in a tertiary care hospital with systematic history documentation, preoperative examinations and post-operative follow-up. Statistical Analysis- Data was collected and compiled in Excel sheet followed by analysis using software Epi Info and Epi Calc 2000. Data was analysed using Z-test. Settings and Design- This is a descriptive type of study conducted for a period of two years. RESULTS Maximum CRC patients were in the age group of 30-40 years, mean age 47 years. Rectum was affected more than right and left colon. Ulceroproliferative is the most common morphology observed. Non-mucinous adenocarcinoma is the commonest microscopic variant seen. 16 cases (out of 62) of CRC presented to the emergency department. Patients presented mostly in advanced stage (stage III and IV). 30 of 62 patients received neo-adjuvant therapy. 45 cases went for complete pathological margin negative (R0) resection of carcinoma. Young patients (<40 years) needed more adjuvant therapy and had statistically significant increased incidence of recurrence and metastasis. CONCLUSION Incidence of CRC is remarkable among patients <40 years. It is comparatively an aggressive disease with poorer prognosis among young patients.
Authors and Affiliations
Partha Pratim Sinha Roy, Dwaipayan Samaddar, Gautam Das
Keywords
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- EP ID EP538618
- DOI 10.14260/jemds/2018/757
- Views 66
- Downloads 0
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