STUDY OF BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN IN SAMPLES RECEIVED FROM PATIENTS ATTENDING TERTIARY CARE HOSPITAL IN MUMBAI
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 3
Abstract
BACKGROUND Bacterial infections are important cause of morbidity and mortality among patients and antimicrobial resistance is a significant growing global threat. In this era of multidrug resistance, it is mandatory to know the bacteriological profile and antimicrobial sensitivity pattern of one’s own institute. Hence, the following study was conducted to document the common bacteria isolated from various clinical specimens from patients of our institute and describe their antibiotic susceptibility. MATERIALS AND METHODS The study was carried out in the Department of Microbiology from January 2016 to December 2016 in our institute. The study included 12,429 clinical samples comprising urine, blood, sputum, stool, pus, wound swabs, catheter tips, nasal swabs, throat swabs, vaginal swabs, sterile body fluids and tissue which were processed for culture, identification and antibiotic susceptibility testing as per standard recommended procedures. RESULTS Samples received were urine 55%, blood 21%, sputum 12%, wound swabs 3%, pus 2.5%, stool 2%, catheter tips 1%, body fluids 1% followed by others. Sample received from males and females were 47% and 53%, respectively. Samples received from 13 - 65 years’ age group, geriatric age group, paediatric age group and neonates were 69.4%, 24%, 6% and 0.6% respectively. Samples received from Outpatient Department (OPD), Inpatient Department (IPD) and Intensive Care Unit (ICU) were 54%, 43% and 3% respectively. 3,014 different bacterial pathogens were isolated. The prevalence of Gram negative bacilli was 90% and that of Gram positive bacilli was 10%. Out of all isolates 60% were from OPD samples, 37% from IPD samples and 3% from ICU samples. Among the pathogens isolated, Escherichia coli was 40% followed by Klebsiella pneumoniae 27%, Pseudomonas aeruginosa 13.4% and Staphylococcus aureus 8% followed by others. Most of the Gram-negative isolates were sensitive to carbapenems, aminoglycosides and beta lactam - beta lactamase inhibitor combinations. Approximately, half of them were sensitive to third and fourth generation cephalosporins and fluoroquinolones. Most of the Gram-positive isolates were sensitive to tetracycline, clindamycin, nitrofurantoin, glycopeptides and vancomycin, but resistant to erythromycin, trimethoprim/ sulfamethoxazole and fluoroquinolones. CONCLUSION In general, most of our Gram-negative isolates showed good sensitivity to carbapenems, aminoglycosides and beta lactam - beta lactamase inhibitor combinations. Sensitivity to cephalosporins and fluoroquinolones prevailed amongst half of them. High resistance to fluoroquinolones was seen among Gram positive isolates also. Methicillin resistant Staphylococcus aureus (MRSA) prevalence was not very high. Such type of surveillance done regularly can help in optimising antibiotic use and thus help to curb antimicrobial resistance.
Authors and Affiliations
Sunayana Mukesh Jangla, Raji Naidu
Keywords
Related Articles
- EP ID EP284614
- DOI 10.14260/jemds/2018/63
- Views 95
- Downloads 0
KLIPPEL TRENAUNAY SYNDROME: A CASE REPORT
[b] INTRODUCTION[/b]: Klippel Trenaunay Syndrome is a rare congenital disorder, but it is the most common condition involving combined vascular malformation. KTS was first described by two French Physicians, Klippe...
OPEN KUNTSCHER NAILING OF FEMUR SHAFT FRACTURE- ITS RELEVANCE IN PRESENT ERA OF INTERLOCK NAILING
BACKGROUND Femur shaft fracture is a common injury seen in road traffic accidents and other high energy trauma. Kuntscher nailing was a popular method of fixation before interlocking intramedullary nail has come into pra...
AUTOIMMUNE HEMOLYTIC ANEMIA IN A PATIENT WITH ENDOBRONCHIAL TUBERCULOSIS
-A 23 year old male presented with severe autoimmune hemolytic anemia in association with constitutional symptoms suggestive of TB with calcified lesion on X ray chest. A diagnosis of endobronchial TB was confi...
CAECAL VOLVULUS- A CASE REPORT
CASE PRESENTATION An 18-year-old female presented to surgical emergency with complaints of progressive abdominal distension, vomiting, constipation and fever of 3 days duration. On examination, she was febrile. Abdomen w...
A STUDY OF ASSOCIATION OF ABO BLOOD GROUP TYPES AND ABH SECRETOR STATUS IN PATIENTS OF TYPE II DIABETES MELLITUS IN KADAPA DISTRICT
BACKGROUND Diabetes Mellitus (DM) is a syndrome characterized by hyperglycaemia resulting from defects of insulin secretion and/or increased cellular resistance to insulin. Diabetes Mellitus is a common medical problem h...