Assessment of Free Testosterone and FSH in Sudanese Alcoholic Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Alcoholism can lead to various medical complications, like perturbed alcohol metabolism, liver cirrhosis and hormonal changes associated with pancreatitis, osteoporosis, immune impairment and impaired fertility. Experimental and clinical studies suggest that alcohol consumption may alter both testosterone secretion and spermatogenesis. This study was carried out to measure serum levels of free testosterone and FSH in Chronic alcoholic patients. Sixty samples were collected from patients in period between February to March 2017, chosen randomly from Omdurman- Khartoum state (Sudan) and Sixty apparently, healthy individuals as controls, to assess the levels of free testosterone and FSH in Chronic alcoholic patients. Serum free testosterone and FSH were measured by using ELISA,(Enzyme -linked immunosorbent assay) and results were analyzed using statistical of package social science (SPSS), computer program. The study showed that, the serum level of free testosterone was significantly decrease, While the level of FSH was significantly increase (p-value =0.00) in alcoholic patients compared to control group. Mean ±SD cases versus control. (8.911±4.89 versus 10.02±8.57) For testosterone. (13.48±7.97 versus 7.28±3.67) for FSH. Also the result showed, there was significant decrease in mean level of testosterone and significant increase in FSH in alcoholic patients that intake alcohol daily compared to alcoholic patients intake alcohol sometimes pear weak. (9.81±5.42 versus 10.13±6.78) for testosterone (16.93±10.27 versus 7.28±3.67) for FSH There was significantly weak positive correlation between serum FSH in alcoholic patients and age of patients ( r= 0.327 , p- value = 0.041) , while there were no correlations between serum testosterone level and age of alcoholic patients ( r=0.008, p- value= 0.953 ). The result showed, there was significant positive correlation between FSH level and duration of alcohol intake(r=0.382, p- value=0.003), while there was insignificant weak negative correlation between testosterone level and duration of alcohol intake (r=-0.168, p- value=0.078) and significant negative correlation between testosterone level and FSH level in alcoholic patients(r= -0.311, p –value=0.016) It is concluded that; the levels of testosterone is significantly decrease and the level of FSH is significantly increase in alcoholic patients compared to control group.
Authors and Affiliations
Nuha Eljaili Abubaker, MUSAAB HAMAD SAAD, Ayman Makki Elgassim
Keywords
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- EP ID EP243594
- DOI 10.9790/0853-1610048489.
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