Comparative Efficacy and Acceptability Profile of Prostaglandin E1, Nitric Oxide Donors and their combination in Pre-Operative Cervical Priming for Surgical Evacuation of Missed Miscarriages: A Randomised Controlled Trial
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Background: Cervical ripening is an essential pre requisite for surgical evacuation in missed miscarriages. This requires an agent that can ripen the cervix effectively with minimal adverse effects. Patients & Methods: In this three group randomised controlled trial we have compared group M (misoprostol 400µg), group – I (40mg Isosorbide mono nitrate – ISMN) and group – C (combination of misoprostol 400µg and 40mg ISMN). All patients were administered the drug at zero hour and were assessed for desired dilatation which was taken as easy negotiation of a Hegar dilator – 10 (HD-10). They were assessed every 3 hours and those with ripened cervix were taken for surgical evacuation. Those who didn’t meet the end point were again administered the drug/s. Intra-operative blood loss and procedural time were noted. Adverse effects were recorded. Results: Statistically significant difference was noted at each assessment with maximum dilatation in group – C and least in group – I. No of doses were also least in group – C and maximum in group – I. Adverse effects were least in ISMN, followed by combination and were highest in misoprostol. Conclusion: Combination appears to synergistically improve therapeutic benefits and reduce the adverse events.
Authors and Affiliations
Amatunnafe Naseha, Mohammed Ismail Khan, Asna Yasmeen
Keywords
Related Articles
- EP ID EP244093
- DOI 10.9790/0853-1610076775
- Views 68
- Downloads 0
“Role of G6PD enzyme in neonatal jaundice and its effects on RBC indices”
Glucose-6-phosphate dehydrogenase deficiency is the most common clinically significant red blood cell enzyme defects in human biology. This cross sectional study was carried out to observe the G6PD status in 90 male, ter...
Anatomical Study of Pulmonary Fissures and lobes in Human Cadavers
The fissures in lung allows uniform expansion. Awareness of Anatomical variations in lung fissures is essential during segmental resection of lungs Anatomical variations of lungs including number, fissures and lobes are...
Vacterl Association in A Newborn – A Rare Case Report
Vacterl association is sporadic non-random co-occurence of various congenital malformations in a single patient due to defect in structures derived from embryonic mesoderm. Here, we report a newborn baby who had most of...
Hemoglobin Electrophoretic Patterns in Punjabi Children With Anemia
Context: Carrier frequency of hemoglobinopathy ranges from 3-17% in Indian population. Early and accurate diagnosis of type of anemia is imperative and requires the use of hemoglobin electrophoresis. Aims: To find the pr...
A Comparative Study of Efficiency Between Anal Fissurectomy And Partial Internal Sphincterotomy For Chronic Anal Fissure
One hundred patients with chronic anal fissure were admitted to the surgical wards of S.V.R.R.G.G. Hospital, Tirupati during the period of August 2016 to November 2017, treated by Anal Fissurectomy or Partial Closed Inte...