“Role of G6PD enzyme in neonatal jaundice and its effects on RBC indices”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Glucose-6-phosphate dehydrogenase deficiency is the most common clinically significant red blood cell enzyme defects in human biology. This cross sectional study was carried out to observe the G6PD status in 90 male, term neonates with jaundice, age ranged from 3 to 12 days (Group B) in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University from 1st July 2007 to 30th June 2008. Our aim was to identify G6PD status in male, term, neonates with jaundice and its effect on hematological parameters including, hemoglobin concentration, hematocrit value, reticulocyte count, RBC count and also different features of peripheral blood film . On the basis of total serum bilirubin level, study group was further divided into three groups: Group B1 (TSB <15mg/dl), GroupB2 (TSB 15-20mg/dl) and Group B3 (TSB>20mg/dl). For comparison, age and sex matched 30 apparently healthy neonates (Group A) were also studied. Study group was selected from in patient and control group from outpatient department of Dhaka Shishu Hospital. Erythrocyte G6PD level, serum bilirubin, ALT and hematological parameters like hemoglobin concentration, hematocrit, total count of RBC,MCV,MCHC, RDW reticulocyte count, were measured and peripheral blood film was examined on the 2nd day of their admission or visit. Erythrocyte G6PD level was measured by Spectrophotometric method by using kit of Randox. All other hematological and biochemical parameters were done by standard laboratory technique. For statistical analysis Anova, independent sample t test and Pearson’s correlation coefficient test were performed as applicable by using SPSS for windows version-12. Study revealed that Hemoglobin concentration, hematocrit value and RBC count were significantly lower in both moderate (p<0.05) and severe (p<0.01) groups in comparison to those of control and mild group .Erythrocyte G6PD levels were significantly lower in moderate (p<0.01, p<0.05) and severe (p<0.001,p<0.01) hyperbilirubinemic group in comparison to those of control and mild group. Among them, reticulocyte count was significantly (p<0.001) higher in severe hyperbilirubinemic than those of control mild and moderate group. From this study, it is revealed that G6PD deficiency in neonates has changes some hematological factors like decreases Hemoglobin concentration, hematocrit value and RBC count and significantly increases reticulocyte count those who have severe hyperbilirubinemic.
Authors and Affiliations
Nilufa Akhter, Noorzahan Begum, Sultana Ferdausi, Waqar Ahmed Khan
Keywords
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