Assessment of Genetic Mutations in WFS1 & CISD2 in Wolfram Syndrome Human
Journal Title: Online Journal of Neurology and Brain Disorders - Year 2018, Vol 1, Issue 1
Abstract
In this study we have analyzed 30 people. 10 patients Wolfram syndrome and 20 persons control group. The genes WFS1 and CISD2, analyzed in terms of genetic mutations made. In this study, people who have genetic mutations were targeted, with nervous disorders Wolfram syndrome. In fact, of all people with Wolfram syndrome. 10 patients Wolfram syndrome had a genetic mutation in the genes WFS1 and CISD2 Wolfram syndrome. Any genetic mutations in the target genes control group did not show. Wolfram syndrome is a genetic disorder that affects many body systems. The specific characteristics of Wolfram syndrome include: high blood sugar levels due to insulin hormone deficiency (diabetes mellitus) and progressive vision loss due to degeneration of the nerves that transports visual information from the eye to the brain (vision atrophy). Symptoms and Symptoms of Wolfram Syndrome. People with Wolfram syndrome often reveal pituitary gland disorders that lead to excessive urination, hearing loss caused by changes in the inner ear (sensory nervous system depression), problems with the urinary tract, decreased testosterone levels in men (hypogonadism), Nervous or psychiatric disorders [1].
Authors and Affiliations
Shahin Asadi, Mahsa Jamali, Hamideh Mohammadzadeh, Mahya Fattahi
Keywords
Related Articles
- EP ID EP590689
- DOI 10.32474/OJNBD.2018.01.000104
- Views 67
- Downloads 0
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