Assessment Of Lymphatic Vessel Density In Breast Carcinoma Using Immunohistochemical Marker D2-40
Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 4
Abstract
Background: Breast carcinoma is the most common malignant tumor in females and the incidence of this disease has been significantly increased. Metastasis is the leading cause of mortality in patients diagnosed with breast cancer. It relies heavily on development of new blood vessels (angiogenesis) and lymphatics (lymphangiogenesis) Objective: The aim of the present study was to assess the significance of lymphatic vessel quantitation in breast carcinoma. Methods: The study included 50 cases of invasive breast cancer. Lymphatic microvessels were identified by using immunohistochemical stain D2-40 in tumoral and peritumoral area. The microvessels were counted within a 400 x magnification field in the area of highest microvessel density. Result: -Intratumoral lymphatic vessel density and peritumoral lymphatic vessel density in node positive cases was significantly correlated. Conclusion: A significant intra and peritumoral lymphatics vessel density in node positive patients indicate that their expression have clinical utility in defining risk for nodal metastasis in breast cancer.
Authors and Affiliations
Shruti Semwal
Keywords
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