Assessment of Plasma Total Antioxidant Activity in Hypertensive Smokers
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 3
Abstract
Oxidative stress has been found to be involved in the development of endothelial dysfunction leading to hypertension. In addition, smoking has been found to be associated with increased production of free radicals & endothelial dysfunction. The objectives of present study were to ascertain the plasma TAA and erythrocyte malondialdehyde (MDA) levels in normotensive and hypertensive smokers, and to determine their cumulative effect in the development of HT in smokers. In the present study, aforesaid parameters were estimated in 90 subjects (30-60 years), categorized into three groups (30 subjects in each group) depending upon their smoking habit and blood pressure i.e. Healthy non smokers (Control group), normotensive smokers (Group I) and Hypertensive smokers (Group II); and compared it statistically by using student’s t- test. Plasma TAA levels were significantly low (p<0.05, p< 0.001) in Group I and II, as compared to healthy controls where as erythrocyte MDA levels were significantly high in both the study groups (P<0.05 & P<0.001) with respect to controls. Our findings indicate that alteration in plasma total antioxidant status along with oxidative stress (via MDA production) may be responsible for biomolecular deterioration and disturbance in homeostatic control leading to the etiopathogenesis of HT in smokers. Therefore, preventive approach against smoking along with incorporation of antioxidant rich diet could be effective in reducing the incidence of hypertension amongst smokers. Keywords: Free radical, Hypertensive smokers, Lipid peroxidation, Total antioxidant activity.
Authors and Affiliations
Dr. Usha Dudeja Bindal, Dr. Rahul Saxena, Dr. Dilutpal Sharma, Dr. Alok Milton Lal
Keywords
Related Articles
- EP ID EP374326
- DOI -
- Views 66
- Downloads 0
Analysis of scientific and ethical status of drug promotional literatures using WHO guidelines
The prime objective is to evaluate the scientific and ethical status of the drug promotional literatures (DPLs) available in Indian market using World Health Organization (WHO) criteria for ethical medicinal drug promoti...
Paediatric Malignant Soft Tissue Sarcoms: A Clinicopathological Study
Pediatric soft tissue sarcomas (STSs) are a heterogenous group of malignant tumors originating from primitive mesenchymal tissue. They account for 7% of all childhood tumors. Risk-based management allows the pediatric on...
HbA1c as screening biomarker of dyslipidemia in Type 2 Diabetes mellitus patients
Type 2 diabetes mellitus consists of an array of dysfunctions characterized by hyperglycemia and resulting from the combination of resistance to insulin action, inadequate insulin secretion, and excessive or inappropriat...
Uncommon delusion disorder of changed facial expression and dilemma of somatic or sexual subtype
A dermatologist may encounter a patient with somatic delusional disorder. Here, we report a case of an uncommon delusional disorder who had delusion of changed facial expression, who initially presented to a dermatologi...
Varus Thrust in Osteoarthritis Knee
Abstract: Osteoarthritis is a degenerative joint disease involving the cartilage and many of its surrounding tissues. In addition to damage and loss of articular cartilage, there is remodeling of subarticular bone, ost...